DENDRITIC PLASTICITY IN THE EARLY POSTNATAL FELINE RETINA - QUANTITATIVE CHARACTERISTICS AND SENSITIVE PERIOD
DENDRITIC PLASTICITY IN THE EARLY POSTNATAL FELINE RETINA - QUANTITATIVE CHARACTERISTICS AND SENSITIVE PERIOD
复制标题
DOI：
10.1002/cne.902420109
复制
发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
WASSLE, H
中科院分区：
文献类型：
--
作者：
EYSEL, UT;PEICHL, L;WASSLE, H
在出生后3 - 60天的小猫和成年猫中进行视网膜损伤。损伤后的生存时间从4至11个月的视网膜神经节细胞的树突状形态显示逆行标记辣根过氧化物酶或与神经原纤维染色技术。在视网膜病变后的第三天出生后，在视网膜神经节细胞逆行变性的区域相邻的树突状形态的变化。树突区起源于位置偏心的胞体，并延伸到无相邻细胞的区域。朝向无神经节细胞区域的树突比正常延长和增厚。单位面积的树突密度在这部分树突树中增加。生后20、38和56天的损伤引起树突形态的变化越来越弱。所描述的树突可塑性类型的敏感期在出生后40至60岁之间结束。
Retinal lesions were made in kittens between 3 and 60 days postnatal age and it adult cats. After postlesion survival times ranging from 4 to 11 months the dendritic morphology of retinal ganglion cells was revealed by retrograde labeling with horseradish peroxidase or with neurofibrillar staining techniques. After retinal lesions on the third postnatal day changes of dendritic morphology were observed in retinal ganglion cells adjacent to regions of retrograde degeneration. Originating from eccentrically positioned somata the dendritic fields extended into the regions that were free of neighboring cells. The dendrites oriented toward the ganglion-cell-free region were elongated and thicker than normal. The density of dendrites per unit area was increased in this part of the dendritic trees. Lesions on the 20th, 38th, and 56th postnatal days elicited increasingly weaker changes of dendritic morphology. The sensitive period for the type of dendritic plasticity described ends between 40 and 60 postnatally.