Incidence and cost burden of post-thrombotic syndrome
Incidence and cost burden of post-thrombotic syndrome
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DOI：
10.1007/s11239-009-0309-3
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发表时间：
2009-11-01
影响因子：
4
通讯作者：
Heit, John A.
中科院分区：
文献类型：
--
作者：
Ashrani, Aneel A.;Heit, John A.
血栓后综合征(PTS)是深静脉血栓形成(DVT)的长期并发症，表现为患肢肿胀、疼痛、水肿、静脉扩张和皮肤硬化。据估计，PTS影响了23-60%的DVT患者，通常发生在DVT发作后2年内。有症状的深静脉血栓、术后无症状的深静脉血栓和复发的深静脉血栓都是PTS发生的危险因素。PTS的治疗往往无效，与治疗相关的费用代表着医疗负担。因此，预防DVT对于减少PTS，从而改善预后和降低整体医疗成本至关重要。尽管指南推荐，但适当的DVT预防措施仍未得到充分利用。本文对PTS的发生率、危险因素和经济影响进行了评价。提高对PTS的认识，以及预防这种并发症的方法可能有助于减少PTS的发生率，改善患者的长期预后，并降低与治疗相关的成本。
Post-thrombotic syndrome (PTS) is a long-term complication of deep-vein thrombosis (DVT), manifesting as swelling, pain, edema, venous ectasia, and skin induration of the affected limb. PTS has been estimated to affect 23-60% of individuals with DVT, frequently occurring within 2 years of the DVT episode. Symptomatic DVT, post-operative asymptomatic DVT, and recurrent DVT are all risk factors for the development of PTS. Treatment of PTS is often ineffective and treatment-related costs represent a healthcare burden. Therefore, prevention of DVT is essential to reduce PTS, and thus improve outcomes and reduce overall healthcare costs. Although recommended by guidelines, appropriate DVT prophylaxis remains considerably underused. This review evaluates the incidence, risk factors, and economic impact of PTS. Increasing the awareness of PTS, and the methods to prevent this complication may help reduce its incidence, improve long-term outcomes in patients, and decrease resulting costs associated with treatment.