Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma.
Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma.
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DOI：
10.1007/s10147-003-0360-6
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发表时间：
2004-02-01
影响因子：
3.3
通讯作者：
Yaegashi, Nobuo
中科院分区：
文献类型：
--
作者：
Akahiro, Jun-ichi;Konno, Ryo;Yaegashi, Nobuo
BACKGROUND: Interleukin-18 (IL-18), a cytokine produced by macrophages, is capable of inducing T-lymphocyte synthesis of interferon-gamma (IFN-gamma). In this study, for the first time, the serum concentration of IL-18 and its significance as a prognostic indicator was evaluated in patients with epithelial ovarian cancer.METHODS: The serum IL-18 level was measured by an enzyme-linked immunosorbent assay (ELISA) in 69 patients with epithelial ovarian cancer and 8 healthy controls. Relationships between the IL-18 level and clinicopathological features were examined by univariate and multivariate analyses.RESULTS: The median serum IL-18 level in the ovarian cancer patients was 229.6 pg/ml, and the level was significantly elevated compared with that in the normal controls (151.3 pg/ml; P < 0.01). No significant correlations were detected between the IL-18 level and stage or histology (P = 0.08 and P = 0.12, respectively). On univariate analysis, overall survival was shown to be affected by IL-18 serum levels. However, multivariate analysis failed to demonstrate an independent prognostic significance for IL-18 serum levels, while confirming the role of previously established prognostic variables, such as performance status, stage, and residual tumor.CONCLUSION: This study showed that IL-18 serum levels were elevated in ovarian cancer patients and were correlated with overall survival, although they were shown not to be an independent prognostic factor.
