MLL2:: A new mammalian member of the trx/MLL family of genes
MLL2:: A new mammalian member of the trx/MLL family of genes
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DOI：
10.1006/geno.1999.5860
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发表时间：
1999-07-15
期刊：
影响因子：
4.4
通讯作者：
Diaz, MO
中科院分区：
文献类型：
--
作者：
FitzGerald, KT;Diaz, MO
我们在染色体19q13.1带确定了一个基因，它与MLL密切相关。MLL位于染色体11q23区域，该区域与染色体19q部分同线。我们将位于19q13.1的这个基因命名为MLL2。MLL2编码的一种蛋白质在几个重要的蛋白质结构域上与MLL表现出高度的相似性。MLL2在成人人体组织中也广泛表达，MLL也是如此。MLL是果蝇基因trithorax（trx）的同源物，trx编码一种同源异型基因表达的调节因子。MLL参与哺乳动物中与白血病相关的染色体重排。然而，尚未有与白血病相关的MLL2重排的记录。（C）1999年学术出版社
We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded. (C) 1999 Academic Press.