Extracellular matrix and traumatic brain injury.

Extracellular matrix and traumatic brain injury.
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DOI:
10.1002/jnr.24151
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发表时间:
2018-04
影响因子:
4.2
通讯作者:
Geller HM
Geller HM
中科院分区:
医学3区
文献类型:
--
作者:
George N;Geller HM

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脑细胞外基质(ECM)通过提供结构支持和介导细胞间相互作用,在发育和成人大脑中起着至关重要的作用。在这篇综述中,我们重点介绍了脑外膜的主要成分及其在正常和损伤脑中的功能,并总结了脑外膜成分的变化以及这些变化如何促进或抑制创伤性脑损伤(TBI)后的功能恢复。通过调节ECM成分来促进神经元的存活、再生和轴突的生长是创伤性脑损伤治疗的潜在治疗靶点。
The Brain Extracellular Matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following Traumatic Brain Injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.
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