Native American Genomics and Population Histories
Native American Genomics and Population Histories
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DOI：
10.1146/annurev-anthro-102215-100036
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Miro-Herrans, Aida T.
中科院分区：
文献类型：
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作者：
Bolnick, Deborah A.;Raff, Jennifer A.;Miro-Herrans, Aida T.
过去十年，人类学遗传学的重要发展改变了对美洲原住民遗传多样性和人口历史的研究。在此期间，研究人员采用了新的 DNA 技术和计算方法来分析基因组数据，并且他们对研究参与者和社区的观点变得越来越敏感。随着新方法应用于解决长期存在的问题，以及与土著社区合作进行更多研究，我们对土著居民的历史和多样性有了新的认识。这篇综述讨论了最近的方法学进展和遗传学研究，这些进展提高了我们对美洲原住民基因组学和人口历史的理解。我们综合了有关美洲原住民基因组变异的当前知识，并建立了美洲人口历史模型。我们还讨论了这项研究对人类学和相关学科的更广泛的影响，并强调了未来研究的挑战和其他考虑因素。
Studies of Native American genetic diversity and population history have been transformed over the last decade by important developments in anthropological genetics. During this time, researchers have adopted new DNA technologies and computational approaches for analyzing genomic data, and they have become increasingly sensitive to the views of research participants and communities. As new methods are applied to long-standing questions, and as more research is conducted in collaboration with indigenous communities, we are gaining new insights into the history and diversity of indigenous populations. This review discusses the recent methodological advances and genetic studies that have improved our understanding of Native American genomics and population histories. We synthesize current knowledge about Native American genomic variation and build a model of population history in the Americas. Wealso discuss the broader implications of this research for anthropology and related disciplines, and we highlight challenges and other considerations for future research.