Controlling cell adhesion using layer-by-layer approaches for biomedical applications
Controlling cell adhesion using layer-by-layer approaches for biomedical applications
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DOI：
10.1016/j.msec.2016.03.074
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发表时间：
2017-01-01
影响因子：
7.9
通讯作者：
Loh, Xian Jun
中科院分区：
文献类型：
--
作者：
Guo, Shanshan;Zhu, Xiaoying;Loh, Xian Jun
在组织工程、抗菌涂层、植入性生物材料和生物传感器等生物医学领域，控制哺乳动物和细菌细胞在合成材料和生物环境之间的粘附性是一个真正的挑战。众所周知，材料的表面性质对粘接过程有着深远的影响。为了调节附着过程，已使用聚合物涂层对表面进行功能化处理，以引入不同的物理化学性质。由Moehwald、Decher和Lvov在20年前提出的通过逐层(LBL)方法构建的聚电解质多层膜已经导致了从对细胞过程的基本了解到控制生物医学应用中的细胞黏附的重大发展。在这篇综述中，我们将重点关注利用LBL方法对表面物理化学性质进行修饰，以构建能够促进或抑制哺乳动物/细菌细胞黏附的薄膜。我们还讨论了新兴的多功能表面领域，这些表面能够对特定的细胞活动做出反应，但对其他细胞活动是惰性的。(C)2016年，由爱思唯尔出版。
Controlling the adhesion of mammalian and bacterial cells at the interfaces between synthetic materials and biological environments is a real challenge in the biomedical fields such as tissue engineering, antibacterial coating, implantable biomaterials and biosensors. The surface properties of materials are known to profoundly influence the adhesion processes. To mediate the adhesion processes, polymeric coatings have been used to functionalize surfaces to introduce diverse physicochemical properties. The polyelectrolyte multilayer films built via the layer-by-layer (LbL) method, introduced by Moehwald, Decher, and Lvov 20 years ago, has led to significant developments ranging from the fundamental understanding of cellular processes to controlling cell adhesion for biomedical applications. In this review, we focus our attention on the modification of surface physicochemical properties, using the LbL approach, to construct films which can either promote or inhibit mammalian/bacterial cell adhesion. We also discuss the emerging field of multifunctional surfaces capable of responding to specific cellular activity but being, inert to the others. (C) 2016 Published by Elsevier B.V.