Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease A meta-analysis
Gene polymorphism associated with TNF-α (G308A) IL-6 (C174G) and susceptibility to coronary atherosclerotic heart disease A meta-analysis
复制标题
DOI：
10.1097/md.0000000000013813
复制
发表时间：
2019-01-01
期刊：
影响因子：
1.6
通讯作者：
Liu Li
中科院分区：
文献类型：
--
作者：
Jiang Yuepeng;Xiaoxuan Zhao;Liu Li
为探讨肿瘤坏死因子-α（TNF-α）G308 A、白细胞介素-6（IL-6）C174 G基因多态性与冠状动脉粥样硬化性心脏病（CHD）发病风险的关系，采用计算机收集相关病例对照研究。筛选出35篇文献，采用Stata 12.0软件进行Meta分析，评价相关性强度。其中17篇研究与TNF-α（G308 A）基因突变和CHD有关，18篇研究与IL-6（C174 G）基因突变有关。根据种族亚组分析结果，提示在亚洲人的所有模型下，TNF-alpha（G308 A）多态性与CHD风险均无显著相关性（P>.05）。亚组分析后，在高加索人中，IL-6 C174 G多态性在所有模型下均与CHD风险无关（P>.05）。现有证据表明，TNF-alpha（G308 A）与亚洲人CHD的风险无关; IL-6（C174 G）基因与高加索人CHD的风险无关。
To evaluate the association between gene polymorphisms of TNF-alpha G308A, IL-6 C174G, and coronary atherosclerotic heart disease (CHD) risk.We used computers to collect related case-control studies. After screening, a meta-analysis was conducted to assess the strength of association by Stata 12.0 software.Thirty-five articles were included. Among them, 17 studies were related to TNF-alpha (G308A) gene mutation and CHD, and 18 studies examined IL-6 (C174G) gene mutation. According to the results of subgroup analysis of ethnicity, it suggested that TNF-alpha (G308A) polymorphism was not significantly associated with CHD risk under all models in Asians (P>.05). There were no connected of IL-6 C174G polymorphism with CHD risk under all models in Caucasians after subgroup analysis (P>.05).The present evidence shows that TNF-alpha (G308A) have no connected with the risk of CHD in Asians; IL-6 (C174G) gene were not associated with the risk of CHD in Caucasians.