New tumor regression grade for rectal cancer after neoadjuvant therapy and radical surgery
New tumor regression grade for rectal cancer after neoadjuvant therapy and radical surgery
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DOI：
10.18632/oncotarget.6008
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发表时间：
2015-12-08
期刊：
影响因子：
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通讯作者：
Lv, Bo
中科院分区：
文献类型：
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作者：
Li, Jun;Liu, Hao;Lv, Bo
在这项回顾性研究中，我们定义了一个新的肿瘤消退等级（NTRG），用于评估2004年6月至2011年10月期间接受新辅助治疗并接受根治性手术的局部晚期直肠癌患者的预后。根据TRG加上淋巴结评分计算，确定了347例患者的NTRG：NTRG 0，46例患者（13.3%）; NTRG 1，63例（18.2%）; NTRG 2，183例（52.7%）; NTRG 3，30例（8.6%）; NTRG 4，25例（7.2%）。其中NTRG 0级45例（97.8%），NTRG 1级56例（88.9%），NTRG 2级148例（80.9%），NTRG 3级24例（66.7%），NTRG 4级10例（40.0%）患者5年无病生存。我们还发现NTRG与5年局部复发、远处转移和无病生存率显著相关（P分别为0.004、0.007和0.039）。因此，NTRG可能是直肠癌患者新辅助治疗和根治性手术后肿瘤学结局的独立预后因素，但这一结论必须在随机试验中得到验证。
In this retrospective study, we defined a new tumor regression grade (NTRG), which we used to evaluate the prognosis of patients with locally advanced rectal cancer who received neoadjuvant therapy and then underwent radical surgery between June 2004 and October 2011. Calculated as the TRG plus a lymph node score, the NTRG was determined for 347 patients: NTRG 0, 46 patients (13.3%); NTRG 1, 63 (18.2%); NTRG 2, 183 (52.7%); NTRG 3, 30 (8.6%); NTRG 4, 25 (7.2%). Among this group, 45 (97.8%) NTRG 0, 56 (88.9%) NTRG 1, 148 (80.9%) NTRG 2, 24 (66.7%) NTRG 3, and 10 (40.0%) NTRG 4 patients experienced 5-year disease-free survival. We also found that NTRG is significantly associated with 5-year local recurrence, distant metastasis and disease-free survival (P = 0.004, 0.007 and 0.039, respectively). The NTRG may thus be an independent prognostic factor for oncologic outcomes in rectal cancer patients after neoadjuvant therapy and radical surgery, but this conclusion must be validated in randomized trials.