Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study
Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study
复制标题
DOI：
10.1192/bjp.bp.111.092098
复制
发表时间：
2012-05-01
影响因子：
10.5
通讯作者：
Tsai, Hui-Ju
中科院分区：
文献类型：
--
作者：
Chen, Shaw-Ji;Chao, Yu-Lin;Tsai, Hui-Ju
BackgroundThe协会之间的自身免疫性疾病和精神分裂症很少被系统地investigated.AimsTo探讨精神分裂症和各种自身免疫性疾病之间的关联，并探讨可能的性别差异在任何这样的association.MethodTaiwan的国民健康保险研究数据库被用来确定10811精神分裂症和108110年龄匹配的对照住院患者。分别进行单因素和多因素logistic回归分析，以评估自身免疫性疾病与精神分裂症之间的关系。结果与对照组相比，住院精神分裂症患者发生Graves病的危险性增加（比值比（OR）= 1.32，95% CI 1.04-1.67），银屑病（OR = 1.48，95%CI 1.07-2.04），恶性贫血（OR = 1.71，95% CI 1.04-2.80），乳糜泻（OR=2.43，95% CI 1.12-5.27）和过敏性血管炎（OR = 5.00，95%CI 1.64-15.26），而与类风湿性关节炎（OR=0.52，95%CI 0.35-0.76）也存在反向关联。性别特异性的变化被发现为干燥综合征，遗传性溶血性贫血，重症肌无力，风湿性多肌痛和皮肌炎。精神分裂症和自身免疫性疾病的病因学还需要进一步的研究。
BackgroundThe association between autoimmune diseases and schizophrenia has rarely been systematically investigated.AimsTo investigate the association between schizophrenia and a variety of autoimmune diseases and to explore possible gender variation in any such association.MethodTaiwan's National Health Insurance Research Database was used to identify 10811 hospital in-patients with schizophrenia and 108110 age-matched controls. Univariate and multiple logistic regression analyses were performed, separately, to evaluate the association between autoimmune diseases and schizophrenia. We applied the false discovery rate to correct for multiple testing.ResultsWhen compared with the control group, the in-patients with schizophrenia had an increased risk of Graves' disease (odds ratio (OR) = 1.32, 95% CI 1.04-1.67), psoriasis (OR = 1.48, 95% CI 1.07-2.04), pernicious anaemia (OR = 1.71, 95% CI 1.04-2.80), celiac disease (OR=2.43, 95% CI 1.12-5.27) and hypersensitivity vasculitis (OR = 5.00, 95% CI 1.64-15.26), whereas a reverse association with rheumatoid arthritis (OR=0.52, 95% CI 0.35-0.76) was also observed. Gender-specific variation was found for Sjogren syndrome, hereditary haemolytic anaemia, myasthenia gravis, polymyalgia rheumatica and dermatomyositis.ConclusionsSchizophrenia was associated with a greater variety of autoimmune diseases than was anticipated. Further investigation is needed to gain a better understanding of the aetiology of schizophrenia and autoimmune diseases.