Assessment of a multi-cytokine profile by a novel biochip-based assay allows correlation of cytokine profiles with clinical outcomes in adult recipients of umbilical cord blood transplantation.
Assessment of a multi-cytokine profile by a novel biochip-based assay allows correlation of cytokine profiles with clinical outcomes in adult recipients of umbilical cord blood transplantation.
复制标题
通过基于新型生物芯片的检测对多细胞因子谱进行评估，可以将细胞因子谱与成人脐带血移植受者的临床结果相关联。
DOI：
10.1038/s41409-019-0707-x
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发表时间：
2020
影响因子：
4.8
通讯作者：
Boussiotis,VassilikiA
中科院分区：
文献类型：
--
作者：
Karantanos,Theodoros;Kim,HaesookT;Tijaro-Ovalle,NataliaM;Li,Lequn;Cutler,Corey;Antin,JosephH;Ballen,KarenK;Ritz,Jerome;Politikos,Ioannis;Boussiotis,VassilikiA
To the Editor, Several studies have documented the association between cytokine levels after hematopoietic stem cell transplantation (HSCT) and infections, graft-versus-host disease (GVHD) and veno-occlusive disease, all of which represent main causes of nonrelapse mortality. Correlations between TNF-α or IL-1 levels and development of acute GVHD (aGVHD) are well described [1, 2]. Elevated IL-6 levels have also been associated with aGVHD and chronic GVHD (cGVHD), as well as early transplant-related complications [3]. IL-8 levels have been correlated with persistent neutropenia and graft failure, representing a predictive marker of bacteremia in neutropenic patients after HSCT [3]. Development of methods permitting the simultaneous measurement of multiple cytokines would improve our understanding of the kinetics and biological relevance of these correlations, and could lead to the development of biomarkers of high prognostic significance for posttransplant complications.
