Multiparametric Imaging of Tumor Response to Therapy
Multiparametric Imaging of Tumor Response to Therapy
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DOI：
10.1148/radiol.10091760
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发表时间：
2010-08-01
期刊：
影响因子：
19.7
通讯作者：
Miles, Kenneth A.
中科院分区：
文献类型：
--
作者：
Padhani, Anwar R.;Miles, Kenneth A.
有越来越多的机会在各种器官部位进行多功能成像，检查时间相对较短。每种技术都能产生反映潜在肿瘤或组织生物学特定方面的定量参数。已经出现了许多生物标志物，它们提供了关于肿瘤行为的独特信息，包括对治疗的反应。多参数方法结合了来自不同功能成像技术的信息;这超出了使用任何单一功能技术所能实现的，从而可以更好地理解生物过程和对治疗干预的反应。多参数成像具有许多潜在的临床作用;它可用于药物开发和预测治疗效果。(C)RSNA，2010年
There is an increasing opportunity to perform multifunctional imaging at a variety of organ sites with relatively short examination times. Each technique yields quantitative parameters that reflect specific aspects of the underlying tumor or tissue biology. Many biomarkers have emerged that provide unique information on tumor behavior, including response to treatment. The multiparametric approach combines the information from different functional imaging techniques; this goes beyond what can be achieved by using any single functional technique, thus allowing an improved understanding of biologic processes and of responses to therapeutic interventions. Multiparametric imaging has many potential clinical roles; it is useful for pharmaceutical drug development and for predicting therapeutic efficacy. (C) RSNA, 2010