Multifaceted brain networks reconfiguration in disorders of consciousness uncovered by co-activation patterns
Multifaceted brain networks reconfiguration in disorders of consciousness uncovered by co-activation patterns
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DOI：
10.1002/hbm.23826
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发表时间：
2018-01-01
影响因子：
4.8
通讯作者：
Laureys, Steven
中科院分区：
文献类型：
--
作者：
Di Perri, Carol;Amico, Enrico;Laureys, Steven
鉴于最近的研究表明，功能连接不是一个静态的现象，我们的目的是调查的默认模式网络（DMN）的连接性在患者的意识disorders of consciousness.MethodsResting-state fMRI卷的一个方便的样本17例无反应觉醒综合征（UWS）通过选择后扣带皮层（PCC）中的关键时间点，将控制简化为时空点过程。对提取的PCC时间帧进行空间聚类，以获得8种不同的共激活模式（CAP）。我们研究了空间连接模式的积极和消极的PCC使用CAP和标准的固定方法。结果与对照组相比，患者表现出（i）减少的网络内正相关和网络间负相关，（ii）出现病理性网络内负相关和网络间正相关（用CAP更好地定义），以及（iii）网络内正相关和网络间负相关的病理性增加（仅使用CAP可检测）。与对照组相比，患者表现出DMN样CAP的发生率降低（1-2）。没有组间差异观察到的总framesConclusionCAP揭示在更细粒度的水平，多方面的空间连接重构后，DMN中断UWS患者，这是更复杂的比以前认为的，并建议替代解剖基板的意识。BOLD波动在患者和对照组之间似乎没有区别，这表明BOLD反应代表了信号的内在特征，因此空间配置对意识比BOLD激活本身更重要。《脑地图》39：89-103，2018年。(c)2017年威利期刊公司
IntroductionGiven that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network's (DMN) connectivity in patients with disorders of consciousness.MethodsResting-state fMRI volumes of a convenience sample of 17 patients in unresponsive wakefulness syndrome (UWS) and controls were reduced to a spatiotemporal point process by selecting critical time points in the posterior cingulate cortex (PCC). Spatial clustering was performed on the extracted PCC time frames to obtain 8 different co-activation patterns (CAPs). We investigated spatial connectivity patterns positively and negatively correlated with PCC using both CAPs and standard stationary method. We calculated CAPs occurrences and the total number of frames.ResultsCompared to controls, patients showed (i) decreased within-network positive correlations and between-network negative correlations, (ii) emergence of pathological within-network negative correlations and between-network positive correlations (better defined with CAPs), and (iii) pathological increases in within-network positive correlations and between-network negative correlations (only detectable using CAPs). Patients showed decreased occurrence of DMN-like CAPs (1-2) compared to controls. No between-group differences were observed in the total number of framesConclusionCAPs reveal at a more fine-grained level the multifaceted spatial connectivity reconfiguration following the DMN disruption in UWS patients, which is more complex than previously thought and suggests alternative anatomical substrates for consciousness. BOLD fluctuations do not seem to differ between patients and controls, suggesting that BOLD response represents an intrinsic feature of the signal, and therefore that spatial configuration is more important for consciousness than BOLD activation itself. Hum Brain Mapp 39:89-103, 2018. (c) 2017 Wiley Periodicals, Inc.