Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans
Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans
复制标题
DOI：
10.1161/01.hyp.0000239206.64270.5f
复制
发表时间：
2006-10-01
期刊：
影响因子：
8.3
通讯作者：
Wilkinson, Ian B.
中科院分区：
文献类型：
--
作者：
McEniery, Carmel M.;Wallace, Sharon;Wilkinson, Ian B.
动脉僵硬度是死亡率的独立预测因子，并受多种因素（包括血管平滑肌张力）的调节。然而，内皮功能和动脉硬度和波反射的明确措施之间的关系尚未在健康个体中描述。因此，我们检验了内皮功能与健康个体的主动脉脉搏波速度（PWV）、中心脉压和增强指数呈负相关的假设。在静息状态下测定外周和中心脉压和增强指数，使用脉搏波分析和舌下含服硝酸甘油和吸入沙丁胺醇测定整体内皮功能。还在89例受试者的子集中测定了基线时的主动脉PWV。在另一组受试者（n=89）中，测量主动脉PWV，并评估肱动脉血流介导的扩张作为管道动脉内皮功能的指标。整体内皮功能与主动脉PWV（r=-0.69; P < 0.001）、增强指数（r=-0.59; P < 0.001）、中心脉压（r=-0.34; P < 0.001）和外周脉压（r=-0.15; P=0.03）显著负相关。此外，中心脉压与外周脉压之间的相关性更强。校正潜在混杂因素后，整体内皮功能仍然独立，与主动脉PWV和增强指数呈负相关。主动脉PWV与主动脉内皮功能呈负相关（r=0.39，P < 0.001），校正混杂因素后仍保持独立性。在健康个体中，内皮功能的下降与大动脉硬度、波反射和中心脉压的增加相关。
Arterial stiffness is an independent predictor of mortality and is regulated by a number of factors, including vascular smooth muscle tone. However, the relationship between endothelial function and definitive measures of arterial stiffness and wave reflections has not been described in healthy individuals. Therefore, we tested the hypothesis that endothelial function is inversely correlated with aortic pulse wave velocity (PWV), central pulse pressure, and augmentation index in healthy individuals. Peripheral and central pulse pressure and augmentation index were determined at rest, and global endothelial function was measured using pulse wave analysis and administration of sublingual nitroglycerin and inhaled albuterol. Aortic PWV was also determined at baseline in a subset of 89 subjects. In a separate group of subjects (n=89), aortic PWV was measured and brachial artery flow-mediated dilatation assessed as a measure of conduit artery endothelial function. Global endothelial function was significantly and inversely correlated with aortic PWV (r=-0.69; P < 0.001), augmentation index (r=-0.59; P < 0.001), and central (r=-0.34; P < 0.001) and peripheral pulse pressure (r=-0.15; P=0.03). Moreover, there was a stronger correlation between central rather than peripheral pulse pressure. After adjusting for potential confounders, global endothelial function remained independently and inversely associated with aortic PWV and augmentation index. There was also a significant, inverse relationship between conduit artery endothelial function and aortic PWV (r=0.39, P < 0.001), which remained independent after adjusting for confounding factors. In healthy individuals, a decline in endothelial function is associated with increased large artery stiffness, wave reflections, and central pulse pressure.