Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways.
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways.
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DOI：
10.1146/annurev-pharmtox-010510-100558
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发表时间：
2011
影响因子：
12.5
通讯作者：
Lum L
中科院分区：
文献类型：
--
作者：
Dodge ME;Lum L
由分泌的Hedgehog（Hh）和Wnt信号分子介导的细胞间通讯对于后生动物整个生命周期中细胞命运决策的协调是必不可少的。从几十年的遗传为基础的审讯，构成Hh和Wnt信号转导通路的核心组件已经组装，并建立了这些信号如何在发育过程中阐述不同的身体组织的深刻理解。另一方面，我们无法利用类似的遗传方法来研究成人器官系统，这限制了我们对这些分子如何通过干细胞调节促进组织更新和再生的理解。我们讨论了最近的进展，在使用化学为基础的方法，以实现控制这些途径的活动，在广泛的生物学研究和治疗环境。特别是，我们讨论了独特的实验机会，这些途径的化学调节剂提供在探索癌症干细胞假说。
Cell-cell communication mediated by the secreted Hedgehog (Hh) and Wnt signaling molecules is essential to the coordination of cell fate decision making throughout the metazoan lifespan. From decades of genetically based interrogation, core components constituting the Hh and Wnt signal transduction pathways have been assembled, and a deep appreciation of how these signals elaborate distinct bodily tissues during development has been established. On the other hand, our incapacity to leverage similar genetic approaches to study adult organ systems has limited our understanding of how these molecules promote tissue renewal and regeneration through stem cell regulation. We discuss recent progress in the use of chemically based approaches to achieve control of these pathway activities in a broad range of biological studies and therapeutic contexts. In particular, we discuss the unique experimental opportunities that chemical modulators of these pathways afford in exploring the cancer stem cell hypothesis.
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影响因子：
9.2
作者：
Endoh-Yamagami, Setsu;Evangelista, Marie;Peterson, Andrew S.
通讯作者：
Peterson, Andrew S.
影响因子：
56.9
作者：
Berman, DM;Karhadkar, SS;Beachy, PA
通讯作者：
Beachy, PA
影响因子：
14.8
作者：
Chen, Baozhi;Dodge, Michael E.;Tang, Wei;Lu, Jianming;Ma, Zhiqiang;Fan, Chih-Wei;Wei, Shuguang;Hao, Wayne;Kilgore, Jessica;Williams, Noelle S.;Roth, Michael G.;Amatruda, James F.;Chen, Chuo;Lum, Lawrence
通讯作者：
Lum, Lawrence
DOI：
10.1038/nrc2503
发表时间：
2008-10
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
8
作者：
Chen, Z.;Li, J.;Zhou, H. M.
通讯作者：
Zhou, H. M.