Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats.
Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats.
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DOI：
10.1093/carcin/17.2.373
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发表时间：
1996-02
期刊：
影响因子：
4.7
通讯作者：
M. A. Pereira;L. H. Barnes;V. Steele;G. Kelloff;R. Lubet
中科院分区：
文献类型：
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作者：
M. A. Pereira;L. H. Barnes;V. Steele;G. Kelloff;R. Lubet
吡罗昔康已被证明可以预防偶氮氧甲烷（AOM）诱导的大鼠异常隐窝灶和结肠癌。在这篇文章中，我们评估了吡罗昔康是否也能引起异常隐窝病灶的癌前病变消退，从而预防癌症的发生。雄性fisher -344大鼠在单次皮下注射AOM （30mg /kg体重）前1周或后12周开始在饮食中给予0.125 g/kg吡罗西康。分别于给药后5周、12周、27周和37周测定异常隐窝灶、结肠腺瘤和腺癌的发生率。如果在AOM前1周开始使用吡罗昔康，则在三个初始时间点的异常隐窝灶的发生率降低。当piroxicam的使用延迟到AOM后12周时，异常隐窝灶的产率从12周时的53.8 +/- 8.1灶/结肠降低到27周时的11.1 +/- 2.0。在给予AOM 37周后，结肠肿瘤的产量为0.59 +/- 0.11个肿瘤/动物，而在AOM前1周或AOM后12周开始给予吡罗昔康的大鼠，产量同样降低至0.14 +/- 0.07和0.17 +/- 0.07个肿瘤/动物。因此，吡罗昔康不仅可以预防，而且可以引起异常隐窝灶的消退，这两者都与预防结肠肿瘤有关。
Piroxicam has been shown to prevent azoxymethane (AOM)-induced aberrant crypt foci and colon cancer in rats. In this communication we evaluate whether piroxicam can also cause regression of precancerous lesions identified as aberrant crypt foci, thus preventing the occurrence of cancer. Male Fischer-344 rats were administered 0.125 g/kg piroxicam in their diet starting either 1 week prior to or 12 weeks after a single subcutaneous injection of AOM (30 mg/kg body wt). The yield of aberrant crypt foci and of colon adenomas and adenocarcinomas was determined at 5, 12, 27 and 37 weeks after administering the AOM respectively. When piroxicam was administered starting 1 week prior to AOM the yield of aberrant crypt foci at the three initial time points was reduced. When the administration of piroxicam was delayed until 12 weeks after AOM the yield of aberrant crypt foci was reduced from 53.8 +/- 8.1 foci/colon at 12 weeks to 11.1 +/- 2.0 at 27 weeks. At 37 weeks after administering AOM the yield of colon tumors was 0.59 +/- 0.11 tumors/animal, while in rats administered piroxicam beginning either 1 week prior to or 12 weeks after AOM the yield was similarly reduced to 0.14 +/- 0.07 and 0.17 +/- 0.07 tumors/animal respectively. Thus piroxicam was demonstrated not only to prevent, but also to cause regression of aberrant crypt foci, both of which were associated with the prevention of colon tumors.