Mechanisms of ventricular arrhythmias in heart failure.
Mechanisms of ventricular arrhythmias in heart failure.
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DOI：
10.1007/s11897-005-0018-y
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Schuger, Claudio D
中科院分区：
文献类型：
--
作者：
Ebinger, Matthew W;Krishnan, Subramaniam;Schuger, Claudio D
充血性心力衰竭仍然是全世界死亡和发病的主要原因。大约 50% 的患者死亡方式是突然的。室性心动过速和颤动代表了大多数心律失常；造成这种情况的机制多种多样且复杂。心肌疤痕是折返的有效环境，可能导致缺血性心力衰竭中的许多室性心律失常。钙处理的改变和钾电流的变化可能导致衰竭心脏中早期和延迟后除极的增加。此外，代偿机制可能会通过多种机制变得有害并可能导致心律失常。本文概述了慢性心力衰竭中室性心律失常的发病机制。
Congestive heart failure continues to be a leading cause of mortality and morbidity worldwide. In approximately 50% of these patients, the mode of death is sudden. Ventricular tachycardia and fibrillation represent the majority of arrhythmias; the mechanisms responsible are heterogeneous and complex. Myocardial scar, a potent environment for reentry, is likely to contribute to many of the ventricular arrhythmias in ischemic heart failure. Altered calcium handling and changes in potassium currents may contribute to the increase in early and delayed afterdepolarizations seen in the failing heart. In addition, compensatory mechanisms may become deleterious and potentially arrhythmogenic via a variety of mechanisms. This article provides a general overview of the mechanisms thought to be responsible for ventricular arrhythmias in chronic heart failure.