Established and Novel Cdk/Cyclin Complexes Regulating the Cell Cycle and Development
Established and Novel Cdk/Cyclin Complexes Regulating the Cell Cycle and Development
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DOI：
10.1007/978-3-642-19065-0_16
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Kaldis, Philipp
中科院分区：
文献类型：
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作者：
Gopinathan, Lakshmi;Ratnacaram, Chandrahas Koumar;Kaldis, Philipp
Cdk和细胞周期蛋白家族中新成员的鉴定，其中许多功能仍在出现，为细胞周期调控网络增加了新的方面。这些新的参与者的作用超出了细胞周期进程的经典调控，参与了转录、神经功能和离子转运等多种过程。与Cdks和细胞周期蛋白密切相关的成员，如Speedy/RINGO蛋白，为填补我们对细胞分裂理解中的空白提供了新的见解和希望。本章将提出一个广阔的前景，细胞周期和它的主要监管机构，特别强调研究较少的成员和他们的新兴作用。
The identification of new members in the Cdk and cyclin families, functions for many of which are still emerging, has added new facets to the cell cycle regulatory network. With roles extending beyond the classical regulation of cell cycle progression, these new players are involved in diverse processes such as transcription, neuronal function, and ion transport. Members closely related to Cdks and cyclins such as the Speedy/RINGO proteins offer fresh insights and hope for filling in the missing gaps in our understanding of cell division. This chapter will present a broad outlook on the cell cycle and its key regulators with special emphasis on the less-studied members and their emerging roles.