Calcium regulation in biological systems: Edited by S Ebashi, K Imahori, S Kakinchi and Y Nishiznka. Academic Press, Orlando, FL, USA. $29.50
Calcium regulation in biological systems: Edited by S Ebashi, K Imahori, S Kakinchi and Y Nishiznka. Academic Press, Orlando, FL, USA. $29.50
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生物系统中的钙调节：由 S Ebashi、K Imahori、S Kakinchi 和 Y Nishiznka 编辑。
DOI：
10.1016/0307-4412(85)90103-7
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Jh Walker
中科院分区：
文献类型：
--
作者：
Jh Walker
1983年10月30日至11月4日，国际异种生物研究学会在美国佛罗里达举行了第一次国际研讨会，来自毒理学、药理学、药剂学、环境和农业科学等领域的科学家们聚集在一起，他们都有一个共同的兴趣：外来化合物的代谢。这本书是研讨会的会议记录，所发表的文章是用胶印直接印刷的，印得很清楚。论文分为五个标题。其中包括外源代谢的细胞生物学，在此基础上讨论了参与外源代谢的酶的定位、肝内分布和调节。关于代谢途径预测的论文详细介绍了卤代烃、有机氮化合物和含功能硫基团的异种生物的代谢途径的预测，药物生物转化和分布的立体化学考虑，以及不可代谢的外来化合物。Caldwell和Hutt的论文《代谢途径的预测——现状和未来展望》很好地总结了预测异种生物分子在I和II相反应中的任何代谢途径的问题。其他论文介绍了植物、细菌、水生物种和哺乳动物的比较异种代谢，以及化学毒性的代谢基础。保尔森在他关于比较异种代谢的经济和毒理学重要性的文章中，为讨论外来化合物的比较代谢提供了一个很好的开端。最后，关于代谢生理控制的论文讨论了雄激素对细胞色素P-450的调节，衰老、感染和饮食对外源化合物代谢的影响。
The International Society for the Study of Xenobiotics held its first international symposium in Florida, USA, October 30 to November 4, 1983, and brought together scientists from the fields of toxicology, pharmacology, pharmaceutics, and environmental and agricultural sciences, all with one common interest: metabolism of foreign compounds. This book is the proceedings of the symposium and the articles presented were printed directly by photo offset which came out creditably clearly. Papers were presented under five headings. These include the cell biology of xenobiotic metabolism, under which are discussed the localization, intrahepatic distribution and regulation of enzymes involved in xenobiotic metabolism. Papers on the prediction of metabolic pathways give detailed accounts for the prediction of pathways for the metabolism of halogenated hydrocarbons, organonitrogen compounds and xenobiotics with functional sulphur groups, stereochemical consideration of drug biotransformation and distribution, and unmetabolisable foreign compounds. The paper, Prediction of Metabolic Pathways--Current Status and Future Prospects, by Caldwell and Hutt, presents a good summary of the problems of predicting any metabolic pathway for a xenobiotic molecule both in the phases I and II reactions. Other papers were presented on comparative xenobiotic metabolism in plants, bacteria, aquatic species and mammals, and the metabolic basis of chemical toxicity. Paulson provides an excellent opening to the discussion on comparative metabolism of foreign compounds in his article on the economic and toxicological importance of comparative xenobiotic metabolism. Finally, papers on the physiological control of metabolism discuss androgenic regulation of cytochrome P-450, the effects of aging, infection and diet on the metabolism of foreign compounds.