Vaccination of patients with haematological malignancies with one or two doses of influenza vaccine: a randomised study
Vaccination of patients with haematological malignancies with one or two doses of influenza vaccine: a randomised study
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DOI：
10.1111/j.1365-2141.2005.05582.x
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发表时间：
2005-07-01
影响因子：
6.5
通讯作者：
Linde, A
中科院分区：
文献类型：
--
作者：
Ljungman, P;Nahi, H;Linde, A
开展了一项开放的随机研究，以确定两剂流感疫苗是否比一剂更有效，以诱导70名血液系统恶性肿瘤患者的免疫反应。甲型H1N1流感病毒血清型分别为18%和22%，H3/N2型分别为26%和14%，B型流感病毒分别为25%和22%。在正在进行和停止治疗的患者中，结果是相似的。接受淋巴瘤单抗治疗的患者反应非常差。我们的结论是，两剂流感疫苗并不能改善血液系统恶性肿瘤患者的抗体反应。
An open, randomised study was performed to determine whether two doses of influenza vaccine were more effective than one to elicit an immune response in 70 patients with haematological malignancies. The responses were not improved by two doses compared with one (influenza A virus serotypes H1/N1 18% vs. 22% and H3/N2 26% vs. 14%; influenza B 25% vs. 22%). The results were similar in patients with ongoing and discontinued therapy. Patients treated with monoclonal antibodies for lymphoma had very poor responses. We conclude that two doses of influenza vaccine do not improve the antibody response in patients with haematological malignancies.