Interorgan relationships for glutamine metabolism in normal and acidotic rats.
Interorgan relationships for glutamine metabolism in normal and acidotic rats.
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正常和酸中毒大鼠谷氨酰胺代谢的器官间关系。
DOI：
10.1152/ajpendo.1981.240.5.e519
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Goldstein,L
中科院分区：
文献类型：
--
作者：
Schrock,H;Goldstein,L
在正常、慢性酸中毒和糖尿病酮症酸中毒大鼠中研究了谷氨酰胺的器官间关系。在正常大鼠中，肌肉组织是将谷氨酰胺释放到循环中的主要部位，而非肝内脏床（主要是肠道）是谷氨酰胺摄取的主要部位。正常吸收后大鼠的肝脏也摄取谷氨酰胺。肾脏对正常大鼠循环谷氨酰胺无明显影响。在慢性NH4Cl和HCl酸中毒中，肌肉谷氨酰胺释放加倍。此外，肝脏减少谷氨酰胺摄取并将谷氨酰胺释放到循环中。肌肉和肝脏分别供应慢性酸中毒期间肾脏增加的谷氨酰胺需求的约55%和45%。在酸中毒期间，非肝内脏床无明显变化。在糖尿病酮症酸中毒大鼠中，肾脏对谷氨酰胺的需求增加几乎完全由肌肉提供。肝脏和非肝内脏床无明显变化。
The interorgan relationships for glutamine were investigated in normal, chronically acidotic, and diabetic ketoacidotic rats. In the normal rat, muscle tissue is the major site that releases glutamine into the circulation, and the nonhepatic splanchnic bed (mainly gut) is the major site of glutamine uptake. The liver of normal, postabsorptive rats takes up glutamine also. The kidneys have no significant affect on circulating glutamine in normal rats. In chronic NH4Cl and HCl acidosis, muscle glutamine release doubles. In addition, the liver decreases glutamine uptake and releases glutamine into the circulation. Muscle and liver supply, respectively, about 55 and 45% of the increased glutamine demand of the kidneys during chronic acidosis. No significant changes could be detected in the nonhepatic splanchnic bed during acidosis. In diabetic ketoacidotic rats, the increased demand for glutamine by the kidneys is almost entirely supplied by muscle. No significant changes occur in liver or nonhepatic splanchnic bed.