Chondroitin sulfate glycosaminoglycans function as extra/pericellular ligands for cell surface receptors.
Chondroitin sulfate glycosaminoglycans function as extra/pericellular ligands for cell surface receptors.
复制标题
硫酸软骨素糖胺聚糖充当细胞表面受体的细胞外/细胞周配体。
DOI：
10.1093/jb/mvac110
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Mikami;T.;and Kitagawa;H.
硫酸软骨素 (CS) 链是一类硫酸化糖胺聚糖 (GAG) 多糖，普遍分布在细胞外/细胞周基质中，建立微环境生态位以支持多种细胞事件。 CS链如此广泛的功能不仅归因于它们的硫酸化模式依赖的结构差异，还归因于它们的多种作用模式。尽管长期以来人们都认为CS链作为被动结构支架，通常充当各种体液因子的共同受体和/或储存库，但不同CS链的细胞表面受体分子的发现为CS作为动态细胞外/细胞周信号配体的新模式提供了见解。 Goget 等人最近的一份报告（通过邻近标记测定鉴定 PTPRσ 相互作用蛋白。J. Biochem.2021；169:187–194）也强烈强调了 CS 受体介导的信号通路的生理重要性。在这篇评论中，我们简要介绍了 CS 链作为细胞外/细胞周信号分子的功能。
Chondroitin sulfate (CS) chains, a class of sulfated glycosaminoglycan (GAG) polysaccharides, are ubiquitously distributed in extra/pericellular matrices that establish microenvironmental niches to support a multitude of cellular events. Such wide-ranging functions of CS chains are attributable not only to their sulfation pattern-dependent structural divergence, but also to their multiple modes of action. Although it has long been accepted that CS chains act as passive structural scaffolds that often behave as co-receptors and/or reservoirs for various humoral factors, the discovery of cell surface receptor molecules for distinct CS chains has offered insights into a novel mode of CS function as dynamic extra/pericellular signaling ligands. A recent report by Gonget al.(Identification of PTPRσ-interacting proteins by proximity-labeling assay.J. Biochem.2021; 169:187–194) also strongly reinforced the physiological importance of CS receptor-mediated signaling pathways. In this commentary, we briefly introduce the functional aspects of CS chains as extra/pericellular signaling molecules.