A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers.
A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers.
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DOI：
10.1155/2013/743721
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发表时间：
2013
影响因子：
1.9
通讯作者：
Tworoger SS
中科院分区：
文献类型：
--
作者：
Kang JH;Kueck AS;Stevens R;Curhan G;De Vivo I;Rosner B;Alexander E;Tworoger SS
背景甲状腺状态可能会影响妇科肿瘤的发生，但这种关系的流行病学研究是有限的和不一致的。方法.我们在1976年至2010年的护士健康研究（NHS）和1989年至2011年的NHSII中评估了医生诊断的甲状腺功能减退症和甲状腺功能亢进症的自我报告病史与病历证实的子宫内膜癌（EC;所有浸润性腺癌）和卵巢癌（OC;上皮性卵巢癌或腹膜癌）的相关性。基于汇总队列数据，使用考克斯比例风险模型估计多变量率比（RR）和95%置信区间。结果我们证实了1314例EC和1150例OC。甲状腺功能减退或甲状腺功能亢进病史与EC或OC的风险均无显著相关性。然而，甲状腺功能减退症病史8年以上（中位数）与EC（RR = 0.81; 95% CI = 0.63-1.04;病史持续时间的P趋势= 0.11）和OC（RR = 0.87，95% CI = 0.66-1.15; P趋势= 0.13）无显著负相关。甲状腺功能亢进症病史6年以上（中位数）与EC无显著正相关（RR = 1.69; 95% CI = 0.86-3.30; P趋势= 0.12），但与OC无显著正相关（RR = 1.12; 95% CI = 0.46-2.72; P趋势= 0.95）。结论.甲状腺功能减退或甲状腺功能亢进病史与EC或OC风险无显著相关性。
Background. Thyroid status may influence tumorigenesis of gynecologic cancers, yet epidemiologic studies of this relationship are limited and inconsistent. Methods. We evaluated the association of self-reported history of physician-diagnosed hypothyroidism and hyperthyroidism with medical-record confirmed endometrial (EC; all invasive adenocarcinomas) and ovarian cancer (OC; epithelial ovarian or peritoneal cancers) in Nurses' Health Study (NHS) from 1976 to 2010 and NHSII from 1989 to 2011. Cox proportional hazard models were used to estimate multivariable rate ratios (RRs) and 95% confidence intervals based on pooled cohort data. Results. We confirmed 1314 incident cases of EC and 1150 cases of OC. Neither a history of hypothyroidism nor hyperthyroidism was significantly associated with risk of EC or OC. However, having a history of hypothyroidism for 8+ years (median) was nonsignificantly inversely associated with EC (RR = 0.81; 95% CI = 0.63–1.04; P-trend with history duration = 0.11) and OC (RR = 0.87, 95% CI = 0.66–1.15; P-trend = 0.13). Having a history of hyperthyroidism for 6+ years (median) was non-significantly positively associated with EC (RR = 1.69; 95% CI = 0.86–3.30; P-trend = 0.12) but not OC (RR = 1.12; 95% CI = 0.46–2.72; P-trend = 0.95). Conclusions. A history of hypothyroidism or hyperthyroidism was not significantly associated with risk of EC or OC.