Diverse and essential roles of mammalian vacuolar-type proton pump ATPase: toward the physiological understanding of inside acidic compartments.
Diverse and essential roles of mammalian vacuolar-type proton pump ATPase: toward the physiological understanding of inside acidic compartments.
复制标题
DOI：
10.1016/j.bbabio.2004.04.013
复制
发表时间：
2004-07
期刊：
影响因子：
--
通讯作者：
G. Sun-Wada;Y. Wada;M. Futai
中科院分区：
文献类型：
--
作者：
G. Sun-Wada;Y. Wada;M. Futai
液泡型H ~+-ATP酶（vacuolar-type H ~+-ATP ases，V-ATP酶）是一个多亚基ATP依赖性质子泵家族，参与多种生理过程。它们存在于内膜细胞器如空泡、溶酶体、内体、高尔基体、嗜铬颗粒和包被囊泡中，并酸化这些细胞内区室的腔pH。它们还能将质子泵过专门细胞的质膜，包括破骨细胞和肾脏及男性生殖道的上皮细胞。在这里，我们简要总结了我们最近的研究哺乳动物V-ATPase的多样性和重要的作用。
The vacuolar-type H+-ATPases (V-ATPase) are a family of multi-subunit ATP-dependent proton pumps involved in a wide variety of physiological processes. They are present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, and acidify the luminal pH of these intracellular compartments. They also pump protons across the plasma membranes of specialized cells including osteoclasts and epithelial cells in kidneys and male genital tracts. Here, we briefly summarize our recent studies on the diverse and essential roles of mammalian V-ATPase.