Epstein‐barr virus and cytomegalovirus in relation to testicular‐cancer risk: a nested case‐control study
Epstein‐barr virus and cytomegalovirus in relation to testicular‐cancer risk: a nested case‐control study
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EB 病毒和巨细胞病毒与睾丸癌风险的关系：一项巢式病例对照研究
DOI：
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发表时间：
1999
影响因子：
6.4
通讯作者：
A. Ekbom
中科院分区：
文献类型：
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作者：
O. Akre;L. Lipworth;S. Tretli;A. Linde;L. Engstrand;H. Adami;M. Melbye;A. Andersen;A. Ekbom
有人提出睾丸癌的感染性病因。我们在一项病例对照研究中评估了巨细胞病毒 (CMV) 和 Epstein-Barr 病毒 (EBV) 的血清反应性与睾丸癌风险的关系，该研究包含在一组前瞻性收集的 293,692 名个体的血清样本中。对于确定的 81 例睾丸癌病例中的每例，从队列中随机选择 3 名对照者。使用酶联免疫吸附测定 (ELISA) 和免疫荧光方法测定针对 CMV 和 EBV 的血清 IgG 抗体滴度。比值比（OR）是从条件逻辑回归模型获得的。总体而言，CMV 阳性与睾丸癌之间没有发现关联（OR = 1.08；95% 置信区间 0.60–1.94）； CMV 血清阳性的睾丸精原细胞瘤风险增加 [OR = 1.70 (0.80–3.59)]，而血清阳性与睾丸非精原细胞瘤的风险降低相关 [OR = 0.54 (0.19–1.56)]（异质性 p，0.09）。对于 EBV，病毒衣壳抗原 (VCA) 血清阳性个体患睾丸癌的风险增加 [OR = 2.74 (0.62–12.12)]。结果为感染病因学的假设提供了一些支持，我们建议未来的研究应考虑感染时的年龄。国际。 J. Cancer 82:1–5, 1999。© 1999 Wiley-Liss, Inc.
An infectious etiology of testicular cancer has been suggested. We have evaluated seroreactivity against cytomegalovirus (CMV) and Epstein‐Barr virus (EBV) in relation to testicular‐cancer risk in a case‐control study, nested within a cohort of prospectively collected serum specimens from 293,692 individuals. For each of 81 cases of testicular cancer identified, 3 controls were randomly selected from the cohort. Serum IgG antibody titers against CMV and EBV were determined using enzyme‐linked immunosorbent assays (ELISAs) and immunofluorescence methods. Odds ratios (OR) were obtained from conditional logistic‐regression models. No association was found between CMV positivity and testicular cancer overall (OR = 1.08; 95% confidence interval 0.60–1.94); risk for testicular seminoma was increased among CMV seropositive [OR = 1.70 (0.80–3.59)], whereas seropositivity was associated with decreased risk for testicular non‐seminoma [OR = 0.54 (0.19–1.56)] (p for heterogeneity, 0.09). For EBV, the risk for testicular cancer was increased among individuals seropositive for viral capsid antigen (VCA) [OR = 2.74 (0.62–12.12)]. The results lend some support to the hypothesis of an infectious etiology, and we propose that future studies should take into account age at infection. Int. J. Cancer 82:1–5, 1999. © 1999 Wiley‐Liss, Inc.
消除对慢性病毒感染的耐受性。
DOI：
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发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Jamieson,BD;Somasundaram,T;Ahmed,R
通讯作者：
Ahmed,R