THERMOGENIC DEFECT IN PRE-OBESE OB-OB MICE
THERMOGENIC DEFECT IN PRE-OBESE OB-OB MICE
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DOI：
10.1038/266060a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
JAMES, WPT
中科院分区：
文献类型：
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作者：
TRAYHURN, P;THURLBY, PL;JAMES, WPT
年幼的遗传肥胖小鼠（ob/ob）即使与它们的瘦同伴成对喂养也会肥胖。这是由于异常高的代谢效率，我们认为这是由于基础代谢率（BMR）的“维持增量”减少所致4。所涉及的因素包括食物的热效应和对低于热中性的环境温度的产热反应。支持这一观点的部分证据来自于一项观察，即成熟的ob/obmice，以及至少另外两种基因肥胖的啮齿动物，在暴露于寒冷时无法保持体温。在4°C时，ob/obmouse和Zucker （fa/fa）大鼠均迅速死于低温5,7。在小鼠中，热生成而不是热保存已被确定为引起热调节缺陷的原因5,7。我们现在报告说，对寒冷的反应缺陷是明显的，在断奶前2周左右，携带ob/ obgentype的小鼠可以通过视觉检查确定为肥胖。据此，开发了一种基于对4°C响应的测试，用于鉴定17 d时的ob/obmice。
YOUNG genetically obese (ob/ob) mice develop obesity even when pair-fed to their lean littermates1–3. This is due to an unusually high metabolic efficiency, which we have suggested results from a reduction in the “maintenance increment” to the basal metabolic rate (BMR)4. Factors involved include the thermic effect of food and the thermogenic response to an environmental temperature below thermoneutrality. Part of the evidence supporting this suggestion comes from the observation that matureob/obmice, and at least two other strains of genetically obese rodent, are unable to maintain their body temperature when exposed to cold5–7. At 4 °C both theob/obmouse and the Zucker (fa/fa) rat rapidly die of hypothermia5,7. In the mouse, thermogenesis rather than heat conservation has been established as the cause of the thermoregulatory defect5,7. We now report that a defective response to cold is apparent in preweanling mice bearing theob/obgenotype about 2 weeks before they can be identified as obese by visual inspection. From this a test based on the response to 4 °C has been developed for the identification ofob/obmice at 17 d old.