Pubertal Timing, Androgens, and Obesity Phenotypes in Women at Midlife
Pubertal Timing, Androgens, and Obesity Phenotypes in Women at Midlife
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DOI：
10.1210/jc.2012-1972
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发表时间：
2012-10-01
影响因子：
5.8
通讯作者：
Cedars, Marcelle I.
中科院分区：
文献类型：
--
作者：
Bleil, Maria E.;Appelhans, Bradley M.;Cedars, Marcelle I.
背景：代谢健康或良性肥胖的个体与不健康或有肥胖风险的个体已被区分；然而，人们对形成这些表型的诱发因素知之甚少。 目的：我们的目的是检查以初潮年龄为标志的青春期时机与中年肥胖风险、良性肥胖和健康正常体重表型之间的关系，并描述以游离雄激素指数（FAI）为标志的雄激素在解释初潮年龄与肥胖之间的任何关联中的潜在作用。 表型。设计：该研究是横断面的。背景和参与者：参与者包括 989 名 25-45 岁绝经前女性的多种族社区样本（平均 = 35.2 岁；SD = 5.5 岁）。主要结果指标：通过体重指数和代谢综合征数量定义高危肥胖、良性肥胖和健康正常体重组的成员资格 结果：月经初潮年龄每增加 1 年，与健康正常体重表型相比，出现肥胖风险的概率就会降低 22%。当 FAI 共变时，这种关联性减弱，表明雄激素水平可能是这种关联性的原因。此外，与健康正常体重表型相比，较高的 FAI 与高风险肥胖以及与良性肥胖表型相比，较高的 FAI 独立相关（均 P < 0.05）。结论：与中年健康正常体重表型相比，初潮年龄较小与代谢不健康肥胖表型相关。这种关系可能是由生物可利用雄激素水平驱动的，在具有肥胖风险表型的女性中，生物可利用雄激素水平尤其升高。 （临床内分泌代谢杂志 97：E1948-E1952，2012 年）
Context: Individuals with metabolically healthy or benign obesity vs. unhealthy or at risk obesity have been distinguished; however, the predisposing factors for developing these phenotypes are poorly understood.Objective: Our objective was to examine pubertal timing marked by menarcheal age in relation to at-risk obese, benign obese, and healthy normal-weight phenotypes at midlife and to characterize the potential role of androgens, marked by the free androgen index (FAI), in accounting for any associations between menarcheal age and obesity phenotype.Design: The study was cross-sectional.Setting and Participants: Participants included a multiethnic community sample of 989 premenopausal women ages 25-45 yr (mean = 35.2 yr; SD = 5.5 yr).Main Outcome Measure: Membership in at-risk obese, benign obese, and healthy normal-weight groups was defined by body mass index and number of metabolic syndrome components.Results: With each 1-yr increase in menarcheal age, the probability of having the at-risk obese compared with the healthy normal-weight phenotype decreased by 22%. This association attenuated when FAI was covaried, suggesting androgen levels may account for this association. In addition, higher FAI was independently related to having the at-risk obese compared with the healthy normal-weight phenotype as well as having the at-risk compared with the benign obese phenotype (all P < 0.05).Conclusions: Younger menarcheal age is associated with having the metabolically unhealthy obesity phenotype compared with the healthy normal-weight phenotype at midlife. This relation may be driven by levels of bioavailable androgens, which were especially elevated among women with the at-risk obesity phenotype. (J Clin Endocrinol Metab 97: E1948-E1952, 2012)