High Altitude Renal Syndrome (HARS)
High Altitude Renal Syndrome (HARS)
复制标题
DOI：
10.1681/asn.2010121316
复制
发表时间：
2011-11-01
影响因子：
13.6
通讯作者：
Escudero, Elizabeth
中科院分区：
文献类型：
--
作者：
Hurtado Arestegui, Abdias;Fuquay, Richard;Escudero, Elizabeth
超过1.4亿人长期生活在高海拔（>2400米）缺氧条件下，挑战基本生理。在这里，我们提出了一个简短的历史回顾这些地区的人口和遗传适应和环境因素（如暴露于钴），可能会影响表型反应的证据。我们还审查了一些常见的肾脏生理反应的临床表现为重点。高血压、微量白蛋白尿、肾小球滤过率（GFR）相对稳定，同时伴有红细胞增多症和高尿酸血症，提示高原肾综合征是一种新的临床综合征，我们称之为高原肾综合征（HARS）。ACE抑制剂在减少这些患者的蛋白尿和降低血红蛋白水平方面似乎有效。
More than 140 million people live permanently at high altitude (>2400 m) under hypoxic conditions that challenge basic physiology. Here we present a short historical review of the populating of these regions and of evidence for genetic adaptations and environmental factors (such as exposure to cobalt) that may influence the phenotypic responses. We also review some of the common renal physiologic responses focusing on clinical manifestations. The frequent presentation of systemic hypertension and microalbuminuria with relatively preserved GFR coupled with the presence of polycythemia and hyperuricemia suggests a new clinical syndrome we term high altitude renal syndrome (HARS). ACE inhibitors appear effective at reducing proteinuria and lowering hemoglobin levels in these patients.