Prefrontal set activity predicts rule-specific neural processing during subsequent cognitive performance
Prefrontal set activity predicts rule-specific neural processing during subsequent cognitive performance
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DOI：
10.1523/jneurosci.3887-05.2006
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发表时间：
2006-01-25
影响因子：
5.3
通讯作者：
Passingham, RE
中科院分区：
文献类型：
--
作者：
Sakai, K;Passingham, RE
前额叶神经元已被证明代表任务规则。在这里，我们展示了前额皮质中的规则选择活动影响基于该规则的后续认知表现的机制。使用功能性磁共振成像，我们发现额极皮层与后部区域的相互作用有所不同，具体取决于受试者是否要执行语音或语义任务。此外，我们发现该区域持续的“设定”活动预测了表演期间后部区域可以记录的活动以及表演的速度。我们认为，前额叶集活动并不反映任务规则的简单维护，而是反映为后续认知表现实施规则的过程，并且这是通过与任务执行所涉及的区域的规则选择性交互来完成的。
Prefrontal neurons have been shown to represent task rules. Here we show the mechanisms by which the rule-selective activity in the prefrontal cortex influences subsequent cognitive performance based on that rule. Using functional magnetic resonance imaging, we found that the frontopolar cortex interacted with posterior areas differently depending on whether subjects were going to perform a phonological or semantic task. Moreover, we found that the sustained "set" activity in this region predicted the activity that could be recorded in the posterior areas during the performance, as well as the speed of that performance. We argue that the prefrontal set activity does not reflect simple maintenance of the task rules but the process of implementing the rule for subsequent cognitive performance and that this is done through rule-selective interactions with areas involved in execution of the tasks.