Prevalence of lipid abnormalities in the United States: The National Health and Nutrition Examination Survey 2003-2006
Prevalence of lipid abnormalities in the United States: The National Health and Nutrition Examination Survey 2003-2006
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DOI：
10.1016/j.jacl.2012.05.002
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发表时间：
2012-08-01
影响因子：
4.4
通讯作者：
Ming, Eileen E.
中科院分区：
文献类型：
--
作者：
Toth, Peter P.;Potter, Danielle;Ming, Eileen E.
背景技术背景：低密度脂蛋白胆固醇（LDL-C）升高与心血管事件风险增加之间的相关性已得到充分证实，治疗重点是降低LDL-C。其他脂质异常也与心血管风险增加相关（例如，低高密度脂蛋白胆固醇[HDL-C]、高甘油三酯[TG]和高非HDL-C）。尽管有国家血脂指南，这些血脂异常参数单独或联合的患病率目的：我们通过使用国家健康和营养检查调查（NHANES）数据评估高LDL-C、低HDL-C、高TG、高非HDL-C和混合性血脂异常的患病率，以估计未达到指南推荐的血脂目标的美国成年人的比例。NHANES 2003-2006年空腹血清数据用于根据LDL-C对年龄≥ 20岁的成人进行分类（风险分层特异性），HDL-C（男性，≥ 150 mg/dL）的目标水平与使用NCEP ATP III定义的基础上冠心病（CHD）的风险。（105.3M）的美国成年人有血脂异常：27%（53.5M）有高LDL-C，23%（46.4M）有低HDL-C，30%（58.9M）有高TG。在血清TO水平>= 20 mg/dL的患者中，约13%（25.7 M）的成人具有非HDL-C水平>= 130 mg/dL。此外，21%（42.0M）的美国成年人患有混合性血脂异常（高LDL-C伴低HDL-C和/或高TG），近6%（11.6M）患有所有三种血脂异常。对于LDL-C，估计有23 M患有CHD或CHD等效风险的成年人和17 M ≥ 2具有风险因素但具有Fragrance风险的成年人，
BACKGROUND: The association between increased low-density lipoprotein cholesterol (LDL-C) and increased risk for cardiovascular events is well established, with treatment focusing on LDL-C lowering. Other lipid abnormalities are also associated with increased cardiovascular risk (eg, low high-density lipoprotein cholesterol [HDL-C], high triglycerides [TG], and high non-HDL-C). Despite national lipid guidelines, the prevalence of these abnormal lipid parameters alone or in combination (mixed dyslipidemia) is not well recognized.OBJECTIVE: We assessed the prevalence of high LDL-C, low HDL-C, high TG, high non-HDL-C, and mixed dyslipidemia by using National Health and Nutrition Examination Survey (NHANES) data to estimate the proportions of U.S. adults not at guideline-recommended lipid goals.METHODS: NHANES 2003-2006 fasting blood serum data were used to categorize adults aged >= 20 years by LDL-C (risk stratum-specific), HDL-C (men, = 150 mg/dL) target levels with use of the NCEP ATP III definitions based on coronary heart disease (CHD) risk.RESULTS: An estimated 53% (105.3M) of U.S. adults have lipid abnormalities: 27% (53.5M) have high LDL-C, 23% (46.4M) have low HDL-C, and 30% (58.9M) have high TG. Among patients with serum TO levels >= 20 mg/dL, approximately 13% (25.7M) of adults have non-HDL-C levels >= 130 mg/dL. Also, 21% (42.0M) of U.S. adults have mixed dyslipidemia (high LDL-C with either low HDL-C and/or high TG), with nearly 6% (11.6M) having all three lipid abnormalities. For LDL-C, an estimated 23M adults with CHD or a CHD risk equivalent and 17M >= 2 with risk factors but a Framingham risk