INFLUENCE OF CORONARY PRESSURE AND CORONARY FLOW ON INTRACORONARY BLOOD-VOLUME AND GEOMETRY OF LEFT VENTRICLE
INFLUENCE OF CORONARY PRESSURE AND CORONARY FLOW ON INTRACORONARY BLOOD-VOLUME AND GEOMETRY OF LEFT VENTRICLE
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DOI：
10.1007/bf00588169
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发表时间：
1973-01-01
影响因子：
4.5
通讯作者：
LOCHNER, W
中科院分区：
文献类型：
--
作者：
MORGENSTERN, C;HOLJES, U;LOCHNER, W
在左冠状动脉插管的犬原位心脏中，估计冠状动脉内血容量与冠状动脉灌注压力的关系。电磁测量冠状动脉的流入乘以平均传输时间，通过染料稀释技术获得，确定冠状动脉内血容量。在70 ~ 170 mm Hg冠状动脉灌注压范围内，每100 g湿重冠状动脉内血容量平均值从11.0 ml增加到17.8 ml；增幅约62%。70 mm Hg时，心肌壁由10.4%的冠状动脉内血液组成，170 mm Hg时为15.1%。冠状动脉血流恒定时，随着冠状动脉灌注压的增加，冠状动脉内血容量显著增加。随着冠状动脉灌注压力的增加，血灌注犬原位心脏和离体猫心脏的心脏外容积和心肌壁容积增大，而左心室内容积减小。左心室的平均半径不受冠状动脉灌注压的影响。这种左心室几何形状的变化影响心脏的压力-容积关系，可以解释冠状动脉灌注压力对心脏功能的影响。
Intracoronary blood volume in relation to coronary perfusion pressure was estimated in dog hearts in situ with cannulated left coronary arteries. Electromagnetically measured inflow into coronary arteries times mean transit time, obtained by a dye dilution technique determined the intracoronary blood volume. Within the range from 70 and 170 mm Hg coronary perfusion pressure the mean value of intracoronary blood volume increases from 11.0 to 17.8 ml per 100 g wet weight; an increase of about 62%. The mycocardial wall at 70 mm Hg consists of 10.4% intracoronary blood and at 170 mm Hg of 15.1%. A significant increase in intracoronary blood volume is seen with increasing coronary perfusion pressure at constant coronary flow.With increasing coronary perfusion pressure the outer volume of the heart and the volume of the myocardial wall increases while the inner volume of the left ventricle decreases in blood perfused dog hearts in situ and in isolated cat hearts. The mean radius of the left ventricle is not changed by the coronary perfusion pressure. This change in the geometry of the left ventricle influences the pressurevolume relation of the heart and can explain the effect of coronary perfusion pressure on the performance of the heart.