Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects
Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects
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DOI：
10.1111/j.1464-5491.2006.02001.x
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发表时间：
2006-12-01
影响因子：
3.5
通讯作者：
Xiang, K.
中科院分区：
文献类型：
--
作者：
Hu, C.;Jia, W.;Xiang, K.
目的：以往的研究表明，过氧化物酶体增殖物激活受体δ（PPARD）基因多态性影响胆固醇代谢的白人。在一项单独的研究中，在韩国人群中没有观察到这种关联，但这项研究表明PPARD多态性与体重和空腹血糖之间存在联系。本研究的目的是确定PPARD基因多态性是否影响中国人的葡萄糖和胆固醇代谢。方法选取上海地区663名40岁以上的2型糖尿病患者（287例）和376名非糖尿病对照者（376例）为研究对象，研究PPARD基因-87T/C多态性与体重、胰岛素敏感性、糖脂代谢相关表型的关系。结果在糖耐量正常（NGT）人群中，C等位基因携带者空腹血糖水平显著高于对照组（P = 0.0078），胰岛素敏感性指数（ISI）显著低于对照组（P = 0.0365）。C等位基因携带者的低密度脂蛋白胆固醇（P = 0.0261）和体脂百分比（P = 0.0357）也较高。C等位基因携带者的内脏脂肪有增高的趋势，但差异无显著性（P = 0.0830）。在糖尿病患者中，检测到血浆葡萄糖浓度的类似结果（空腹血糖P < 0.0001，2小时血糖P = 0.0052）和胰岛素敏感性（稳态模型评估胰岛素抵抗P = 0.0094;结论PPARD基因-87T/C多态性与NGT和DM患者空腹血糖升高相关，主要是由于胰岛素敏感性受损。
Aims Previous studies have shown that the peroxisome proliferator-activated receptor delta (PPARD) genetic polymorphism affects cholesterol metabolism in Whites. This association was not observed in a Korean population in a separate study, but this study showed a link between the PPARD polymorphism and body weight and fasting plasma glucose. The purpose of this study was to determine whether polymorphisms of PPARD influence glucose and cholesterol metabolism in Chinese subjects. We investigated the association between the polymorphism (-87T/C) of the human PPARD gene and phenotypes related to body weight, insulin sensitivity, glucose and lipid metabolism in Chinese subjects.Methods Unrelated Chinese subjects (n = 663) in Shanghai were studied; 287 had newly diagnosed Type 2 diabetes mellitus and 376 were non-diabetic control subjects over 40 years old. Clinical parameters were collected and genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism.Results In normal glucose tolerant (NGT) subjects, the C allele carriers had higher fasting plasma glucose concentrations (P = 0.0078) and a lower insulin sensitivity index (ISI) (P = 0.0365). The C allele carriers also showed higher concentrations of low-density lipoprotein cholesterol (P = 0.0261) and percentage of body fat (P = 0.0357). There was a trend towards higher visceral adiposity in C allele carriers, but the difference was nor significant (P = 0.0830). In diabetes patients, similar results were detected for plasma glucose concentrations (fasting plasma glucose P < 0.0001, 2-h plasma glucose P = 0.0052) and insulin sensitivity (homeostasis model assessment of insulin resistance P = 0.0094; ISI P = 0.0058).Conclusion The PPARD -87T/C polymorphism is associated with higher fasting plasma glucose concentrations in both NGT and diabetic subjects, largely due to impaired insulin sensitivity.