Long-Term Escherichia coli Asymptomatic Bacteriuria among Women with Diabetes Mellitus
Long-Term Escherichia coli Asymptomatic Bacteriuria among Women with Diabetes Mellitus
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DOI：
10.1086/600883
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发表时间：
2009-08-15
影响因子：
11.8
通讯作者：
Foxman, Betsy
中科院分区：
文献类型：
--
作者：
Dalal, Shona;Nicolle, Lindsay;Foxman, Betsy
Background. Persistent Escherichia coli asymptomatic bacteriuria (ASB) is common among persons with diabetes mellitus, but the duration of colonization and the rates of recolonization are unknown. We estimated the duration of colonization and the rate of recolonization among successively isolated E. coli from diabetic women with ASB and compared the virulence profiles with uropathogenic and commensal E. coli.Methods. A total of 105 women with diabetes were enrolled in a randomized, controlled clinical trial for treatment of ASB in Manitoba, Canada, and were observed at least every 3 months for up to 3 years. We analyzed 517 isolates from 70 women with repeated E. coli ASB for genetic similarity using enterobacterial repetitive intergenic consensus polymerase chain reaction. Unique strains were screened for uropathogenic virulence characteristics using dot blot hybridization and compared with different collections of E. coli isolates.Results. On average, differences were found among women assigned to treatment for ASB, those treated only for symptomatic infections, and untreated women in (1) follow-up time with bacteriuria (29%, 31%, and 66%, respectively; P
