CONTINUOUS TELEMETRIC BLOOD-PRESSURE MONITORING AND GLOMERULAR INJURY IN THE RAT REMNANT KIDNEY MODEL
CONTINUOUS TELEMETRIC BLOOD-PRESSURE MONITORING AND GLOMERULAR INJURY IN THE RAT REMNANT KIDNEY MODEL
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DOI：
10.1152/ajprenal.1993.265.3.f391
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发表时间：
1993-09-01
影响因子：
--
通讯作者：
LANSKY, DM
中科院分区：
文献类型：
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作者：
BIDANI, AK;GRIFFIN, KA;LANSKY, DM
残肾（RK）模型中肾小球损伤的发病机制仍存在争议。全身性高血压的肾小球传播增加被认为是一个重要的发病机制，但由于尾套法的局限性，全身压力与肾小球损伤之间的精确关系尚未确定。在大约 5/6 肾消融 (n = 16) 或假消融 (n = 7) 后，以 10 分钟的间隔连续记录大鼠的收缩压 (BP)，持续 6 周。 RK 大鼠的总体平均收缩压显着高于假手术大鼠（138 +/- 3.3 vs. 117 +/- 1.3 mmHg，P < 0.01）。此外，与假手术大鼠相比，RK 大鼠的收缩压显着不稳定。肾小球损伤基本上仅限于 RK 大鼠，但受损肾小球的百分比在 1% 至 55% 之间。个体动物的肾小球损伤与最后约 4 周内的平均收缩压以及收缩压读数 >140 mmHg 的频率密切相关 (r = 0.88)。这些数据强烈表明，全身性高血压向肾微脉管系统的传播在 RK 模型中肾小球损伤的发病机制中起主导作用，并且也支持放射遥测技术在研究高血压靶器官损伤方面的潜在用途。
The pathogenesis of glomerular injury in the remnant kidney (RK) model remains controversial. Increased glomerular transmission of systemic hypertension has been postulated to be an important pathogenetic mechanism, but the precise relationship between systemic pressures and glomerular injury has not been defined because of the limitations of the tail-cuff method. Systolic blood pressure (BP) was continuously recorded radiotelemetrically at 10-min intervals for 6 wk in rats after approximately 5/6 renal ablation (n = 16) or sham ablation (n = 7). Overall mean systolic BP in RK rats was significantly higher than sham (138 +/- 3.3 vs. 117 +/- 1.3 mmHg, P < 0.01). Additionally, marked lability of systolic BP was observed in RK rats as compared with sham rats. Glomerular injury was essentially confined to RK rats, but the percentage of injured glomeruli ranged between 1 and 55%. Glomerular injury in individual animals was strongly correlated (r = 0.88) with the mean systolic BP during the last approximately 4 wk and with the frequency of systolic BP readings of >140 mmHg. These data strongly suggest that transmission of systemic hypertension to the renal microvasculature plays a predominant role in the pathogenesis of glomerular injury in the RK model and also support the potential usefulness of the radiotelemetric technique to investigate hypertensive target organ injury.