Arenavirus budding.
Arenavirus budding.
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DOI：
10.1155/2011/180326
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发表时间：
2011
影响因子：
2.2
通讯作者：
de la Torre JC
中科院分区：
文献类型：
--
作者：
Urata S;de la Torre JC
几种沙粒病毒在人类中引起出血热疾病，并在其流行地区造成重大的公共卫生问题。另一方面，原型沙粒病毒LCMV是研究病毒-宿主相互作用和相关疾病的极好工具。沙粒病毒的小环指蛋白Z已被证明是病毒出芽的主要驱动力。Z的出芽活性由位于Z的C末端的晚期（L）结构域基序PT/SAP和PPXY介导。本文将介绍沙粒病毒出芽的现有知识，包括不同沙粒病毒使用的L结构域基序的多样性。我们还将讨论如何提高沙粒病毒出芽的知识可能有助于开发新的抗病毒策略来对抗人类致病性沙粒病毒。
Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease. The arenavirus small RING finger protein called Z has been shown to be the main driving force of virus budding. The budding activity of Z is mediated by late (L) domain motifs, PT/SAP, and PPXY, located at the C-terminus of Z. This paper will present the current knowledge on arenavirus budding including the diversity of L domain motifs used by different arenaviruses. We will also discuss how improved knowledge of arenavirus budding may facilitate the development of novel antiviral strategies to combat human pathogenic arenaviruses.