Cyclic strain in human carotid bifurcation and its potential correlation to atherogenesis: Idealized and anatomically-realistic models
Cyclic strain in human carotid bifurcation and its potential correlation to atherogenesis: Idealized and anatomically-realistic models
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DOI：
10.1023/b:engi.0000007974.82115.16
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发表时间：
2003-12-01
影响因子：
1.3
通讯作者：
Kamm, RD
中科院分区：
文献类型：
--
作者：
Kaazempur-Mofrad, MR;Younis, HF;Kamm, RD
各种机械现象被认为与动脉粥样硬化的发病机制有关。尽管有大量的实验证据表明内皮细胞和平滑肌细胞很容易对循环应变做出反应，但迄今为止，大多数动脉壁力学的有限元分析都集中在机械壁应力的量化上。在这项研究中，我们计算了颈动脉分叉的生理循环应变，这是一种常见的疾病。本研究构建了几种几何模型，即(i)人体颈动脉分叉的三维但理想化的几何模型，（ii）基于健康志愿者颈动脉分叉的体内图像的三维受试者特定几何模型，以及（iii）基于组织学衍生的患者特定解剖结构和斑块内成分的二维模型。两种类型的3d模型的结果显示，在颈外总动脉的相邻壁和颈动脉顶点处发现了最大的循环应变变化，这两个部位都是早期炎症的常见部位，以及颈动脉球囊的远端，这是一个晚期疾病的部位，这表明循环应变可能在该区域的炎症中也起作用。病变动脉的二维模型显示，循环应变一般较弱，但在纤维帽的肩部区域，如脂质池附近，循环应变相当高。
Various mechanical phenomena are thought to contribute to the pathogenesis of atherosclerosis. Most finite-element analyses of arterial-wall mechanics to date have focused on the quantification of mechanical wall stresses, despite an abundance of experimental evidence suggesting that endothelial and smooth muscle cells readily respond to cyclic strain. In this study, we calculate the physiologic cyclic strains in the carotid bifurcation, a common site of disease. Several geometries are constructed in this study, namely (i) a 3-D, but idealized geometry of the human carotid bifurcation, (ii) 3-D subject-specific geometries based on in vivo images of healthy volunteers' carotid bifurcations, and (iii) 2-D models based on histology-derived patient-specific anatomy and intra-plaque components. Results in both types of 3-D model show that the highest variations in cyclic strain are found at the adjoining wall of the external-common carotid and at the carotid apex, both frequent sites of early inflammation, as well as immediately distal to the carotid bulb, a site of late-stage disease, suggesting that cyclic strain may play a role in inflammation in that region as well. The 2-D models of diseased arteries show generally muted cyclic strain, but also regions such as in the shoulder regions of a fibrous cap adjacent to a lipid pool where cyclic strains are considerably elevated.