Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium.
Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium.
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DOI：
10.1038/s41598-017-01977-w
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发表时间：
2017-05-22
影响因子：
4.6
通讯作者：
Linneberg A
中科院分区：
文献类型：
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作者：
Skaaby T;Taylor AE;Jacobsen RK;Paternoster L;Thuesen BH;Ahluwalia TS;Larsen SC;Zhou A;Wong A;Gabrielsen ME;Bjørngaard JH;Flexeder C;Männistö S;Hardy R;Kuh D;Barry SJ;Tang Møllehave L;Cerqueira C;Friedrich N;Bonten TN;Noordam R;Mook-Kanamori DO;Taube C;Jessen LE;McConnachie A;Sattar N;Upton MN;McSharry C;Bønnelykke K;Bisgaard H;Schulz H;Strauch K;Meitinger T;Peters A;Grallert H;Nohr EA;Kivimaki M;Kumari M;Völker U;Nauck M;Völzke H;Power C;Hyppönen E;Hansen T;Jørgensen T;Pedersen O;Salomaa V;Grarup N;Langhammer A;Romundstad PR;Skorpen F;Kaprio J;R Munafò M;Linneberg A
关于吸烟与花粉热和哮喘风险的观察性研究显示了不一致的结果。然而，观察性研究可能因混杂和反向因果关系而产生偏倚。孟德尔随机化使用遗传变异作为暴露的标记来检查因果效应。我们通过使用吸烟相关的单核苷酸多态性（SNP）rs 16969968/rs 1051730研究了吸烟对花粉热和哮喘的因果影响。我们纳入了来自22项基于人群的研究的231，020名参与者。观察分析表明，目前吸烟者与从不吸烟者相比，患花粉热的风险较低（比值比（OR）= 0.68，95%可信区间（CI）：0.61，0.76; P <0.001）（OR = 0.74，95% CI：0.64，0.86; P <0.001），但哮喘风险相似（OR = 1.00，95% CI：0.91，1.09; P = 0.967）。对目前吸烟者的孟德尔随机分析显示，花粉热的风险略低（OR = 0.958，95%CI：0.920，0.998; P = 0.041），过敏性致敏风险较低（OR = 0.92，95%CI：0.84，1.02; P = 0.117），但每个吸烟增加等位基因的哮喘风险更高（OR = 1.06，95%CI：1.01，1.11; P = 0.020）。我们的研究结果表明，吸烟可能与较高的哮喘风险和较低的花粉热风险有因果关系。然而，与吸烟相关的不良事件限制了其临床意义。
Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
影响因子：
3.7
作者：
Kaakinen M;Ducci F;Sillanpää MJ;Läärä E;Järvelin MR
通讯作者：
Järvelin MR