Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets.
Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets.
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DOI：
10.1158/2159-8290.cd-13-0239
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发表时间：
2013-07
期刊：
影响因子：
28.2
通讯作者：
Gutkind JS
中科院分区：
文献类型：
--
作者：
Iglesias-Bartolome R;Martin D;Gutkind JS
发表在这期《癌症发现》杂志上的两项研究描述了头颈部鳞状细胞癌（HNSCC）及其基因组和表观遗传学改变的新突变景观，从而确定了新的可操作的癌症驱动因素和靶向治疗的预测生物标志物。HNSCC中的大多数基因组改变集中在少数分子途径中，导致细胞周期失调、基因组不稳定性、细胞分化缺陷和持续的促有丝分裂信号传导，后者涉及异常的PI 3 K/mTOR途径活化，从而使HNSCC对PI 3 K/mTOR抑制剂有反应。
Two studies published in this issue of Cancer Discovery describe the emerging mutational landscape of head and neck squamous cell carcinomas (HNSCC) and their genomic and epigenetic alterations, thus identifying novel actionable cancer drivers and predictive biomarkers for targeted therapies. Most genomic alterations in HNSCC converge in a handful of molecular pathways resulting in cell cycle deregulation, genomic instability, cell differentiation defects, and persistent mitogenic signaling, the latter involving aberrant PI3K/mTOR pathway activation thereby rendering HNSCC responsive to PI3K/mTOR inhibitors.