CALCIUM HOMEOSTASIS AND BONE METABOLISM DURING PREGNANCY, LACTATION, AND POSTWEANING - A LONGITUDINAL-STUDY
CALCIUM HOMEOSTASIS AND BONE METABOLISM DURING PREGNANCY, LACTATION, AND POSTWEANING - A LONGITUDINAL-STUDY
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DOI：
10.1093/ajcn/61.3.514
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发表时间：
1995-03-01
影响因子：
7.1
通讯作者：
VIEIRA, NE
中科院分区：
文献类型：
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作者：
CROSS, NA;HILLMAN, LS;VIEIRA, NE
对10名妇女进行了连续跟踪，以确定生殖阶段对钙和骨代谢的影响。研究期为非妊娠期非哺乳期、妊娠期每个三个月结束时、哺乳期3个月和断奶后。每个个体的非妊娠非哺乳状态进行比较。钙吸收分数（P < 0.0001）和1，25-二羟维生素D浓度（P < 0.01）在中晚期较高。总尿钙在怀孕期间较高，断奶后较低。甲状旁腺激素（PTH）浓度仅在断奶后显著升高（P < 0.01）。血清抗酒石酸酸性磷酸酶、骨特异性碱性磷酸酶和尿脱氧吡啶啉在孕晚期和哺乳期均升高（P < 0.01）。血清I型前胶原羧基肽仅在妊娠晚期升高（P < 0.01）。单光子吸收法测定的骨密度在不同时期没有差异。我们的结论是，钙的吸收和尿排泄增加在怀孕期间，而骨转换增加在妊娠后期和哺乳期，只有肾脏的变化一致的PTH增加断奶后。
Ten women were followed serially to determine the effect of stages of reproduction on calcium and bone metabolism. The study periods were nonpregnant nonlactating, the end of each trimester of gestation, 3 mo lactation, and postweaning. Comparisons were with nonpregnant nonlactating status for each individual. Fractional calcium absorption (P < 0.0001) and concentrations of 1,25-dihydroxyvitamin D (P < 0.01) were higher in the second and third trimesters. Total urinary calcium was higher during pregnancy and lower postweaning. Parathyroid hormone (PTH) concentrations were higher only postweaning (P < 0.01). Markers of bone turnover increased at the third trimester and during lactation: serum tartrate resistant acid phosphatase and bone specific alkaline phosphatase, and urinary deoxypyridinoline (P < 0.01). Serum procollagen I carboxypeptides increased only in the third trimester (P < 0.01). Bone mineral density by single-photon absorptiometry did not differ by period. We conclude that absorption and urinary excretion of calcium increase during pregnancy whereas bone turnover increases during late pregnancy and lactation; only renal changes consistent with an increase in PTH were seen postweaning.