Isopropanol enhancement of carbon tetrachloride metabolism in vivo.
Isopropanol enhancement of carbon tetrachloride metabolism in vivo.
复制标题
异丙醇增强体内四氯化碳代谢。
DOI：
10.1016/0024-3205(82)90767-6
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
Treinen,RJ
中科院分区：
文献类型：
--
作者：
Reynolds,ES;Moslen,MT;Treinen,RJ
我们检查了异丙醇（ISOP）预处理对呼吸中呼出的 14 CCl 4 至 14 CO 2 和 CHCl 3 代谢、0至24小时在24小时尿液和粪便中排出的to 14 C代谢物以及24小时与肝脏结合的to 14 C代谢物的影响。禁食的雄性大鼠给予0.1或2.0毫摩尔14CCl4/kg。 ISOP预处理显着增强了CCl4的肝毒性，选择性地增强了14CO2和CHCl3代谢物的呼出速率和总量。导致 CO2 和 CHCl3 代谢物形成的 CCl4 代谢途径可能比导致尿液粪便或共价结合代谢物的途径与 CCl4 的肝毒性更相关。
We examined the effects of isopropanol (ISOP) pretreatment on the metabolism of14CCl4to14CO2and CHCl3exhaled in the breath, to14C metabolite excreted in 24 hr urine and feces from 0 to 24 hr, and to14C metabolite bound to liver at 24 hr. Fasted male rats were given 0.1 or 2.0 mmoles14CCl4/kg. ISOP pretreatment, which markedly enhanced the hepatotoxicity of CCl4, selectively enhanced the rate and total extent of14CO2and CHCl3metabolite exhalation. The pathways of CCl4metabolism leading to CO2and CHCl3metabolite formation may be more relevant to the hepatotoxicity of CCl4than the pathways leading to urinarym fecal or covalently bound metabolites.