Neural Substrates of Poststroke Depression: Current Opinions and Methodology Trends.

Neural Substrates of Poststroke Depression: Current Opinions and Methodology Trends.
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中风后抑郁症的神经基质:当前观点和方法论趋势。

DOI:
10.3389/fnins.2022.812410
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发表时间:
2022
影响因子:
4.3
通讯作者:
Zhu, Suiqiang
Zhu, Suiqiang
中科院分区:
医学2区
文献类型:
--
作者:
Pan, Chensheng;Li, Guo;Sun, Wenzhe;Miao, Jinfeng;Qiu, Xiuli;Lan, Yan;Wang, Yanyan;Wang, He;Zhu, Zhou;Zhu, Suiqiang

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中风后抑郁症(PSD)影响约三分之一的中风幸存者,对患者的功能结果和死亡率产生重大影响。自 20 世纪 70 年代以来,人们为揭示 PSD 的神经解剖学基础和大脑行为机制付出了巨大的努力。由于过去二十年神经影像学和计算神经科学的进步,用于揭示局灶性脑损伤引起的症状或行为缺陷的神经基础的新技术已经出现。从病变分析时代到脑网络时代,我们对 PSD 神经基质的认识和理解不断增加。来自传统病变分析、单变量或多变量病变-症状图谱、区域结构和功能分析、直接或间接连接组分析以及 PSD 神经调节临床试验的汇总证据在某种程度上呼应了抑郁症的额叶边缘理论。 PSD 的神经基质将来可用于风险分层和个性化治疗靶点识别。在这篇综述中,我们提供了有关 PSD 神经基础的最新进展的最新进展,其中临床意义和方法学趋势是我们感兴趣的主要特征。
Poststroke depression (PSD), affecting about one-third of stroke survivors, exerts significant impact on patients’ functional outcome and mortality. Great efforts have been made since the 1970s to unravel the neuroanatomical substrate and the brain-behavior mechanism of PSD. Thanks to advances in neuroimaging and computational neuroscience in the past two decades, new techniques for uncovering the neural basis of symptoms or behavioral deficits caused by focal brain damage have been emerging. From the time of lesion analysis to the era of brain networks, our knowledge and understanding of the neural substrates for PSD are increasing. Pooled evidence from traditional lesion analysis, univariate or multivariate lesion-symptom mapping, regional structural and functional analyses, direct or indirect connectome analysis, and neuromodulation clinical trials for PSD, to some extent, echoes the frontal-limbic theory of depression. The neural substrates of PSD may be used for risk stratification and personalized therapeutic target identification in the future. In this review, we provide an update on the recent advances about the neural basis of PSD with the clinical implications and trends of methodology as the main features of interest.
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