The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion.
The dynamic epigenome and its implications for behavioral interventions: a role for epigenetics to inform disorder prevention and health promotion.
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动态表观基因组及其对行为干预的影响：表观遗传学在疾病预防和健康促进中的作用。
DOI：
10.1007/s13142-016-0387-7
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发表时间：
2016
影响因子：
3.6
通讯作者：
Musci,Rashelle
中科院分区：
文献类型：
--
作者：
Szyf,Moshe;Tang,Yi-Yang;Hill,KarlG;Musci,Rashelle
行为表观遗传学这一新兴领域正在产生越来越多的证据，证明早期生活经历和社会接触可以改变DNA甲基化标记基因的方式。我们假设DNA甲基化以及其他表观遗传标记的变化可以产生稳定的表型。早期生活逆境似乎会导致大脑和外周组织基因DNA甲基化的改变，而这些变化与不利的表型变化有关。虽然数据仍然稀少，但早期的表观遗传学研究已经提供了经验和环境在基因上留下印记的原理证明，从而为基因-环境相互作用的流行病学概念提出了分子和物理机制。DNA甲基化对I型（TI）转化预防科学的主要吸引力在于，与从我们祖先遗传的遗传变化不同，DNA甲基化是潜在的可预防和可逆的，因此，有可能进行有针对性的遗传干预。此外，DNA甲基化标记可能为评估早期不良经历对个体风险的影响提供客观工具，并为干预的进展提供客观措施。尽管社会表观遗传学和转化表观遗传学这一新兴领域有着巨大的潜力，但在行为表观遗传学成为转化表观遗传学之前，仍有许多实际的挑战需要解决。
The emerging field of behavioral epigenetics is producing a growing body of evidence that early life experience and social exposure can alter the way by which genes are marked with DNA methylation. We hypothesize that changes in DNA methylation as well as other epigenetic markers could generate stable phenotypes. Early life adversity appears to result in altered DNA methylation of genes in the brain and peripheral tissues, and these changes are associated with adverse phenotypic changes. Although the data are still sparse, early epigenetic studies have provided a proof of principle that experiences and the environment leave marks on genes, and thus suggest molecular and physical mechanisms for the epidemiological concept ofgene-environmentinteraction. The main attraction of DNA methylation for type I (TI) translational prevention science is the fact that, different from genetic changes that are inherited from our ancestors, DNA methylation is potentially preventable and reversible and, therefore, there is a prospect ofepigeneticallytargeted interventions. In addition, DNA methylation markers might provide an objective tool for assessing effects of early adverse experience on individual risks as well as providing objective measures of progress of an intervention. In spite of this great potential promise of the emerging field ofsocial and translational epigenetics, many practical challenges remain that must be addressed beforebehavioral epigeneticscould becometranslational epigenetics.