Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages
Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages
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成人唐氏综合症不同年龄段脑形态定量CT分析
DOI：
10.1212/wnl.37.8.1424
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发表时间：
1987
期刊：
影响因子：
9.9
通讯作者：
S. Rapoport
中科院分区：
文献类型：
--
作者：
M. Schapiro;H. Creasey;M. Schwartz;J. Haxby;B. White;A. Moore;S. Rapoport
定量CT显示，患有唐氏综合征(DS)的健康成年人与对照组相比，大脑和颅内体积都较小。脑脊液、脑室和脑实质的正常化体积在患者和对照组中没有差异。DS受试者和对照组的脑脊液和脑室体积均显示出与年龄相关的显著增加。在七名年龄较大的DS受试者中，有一人患有痴呆症，而与年轻的DS受试者相比，这组人作为一个整体显示出认知测试分数的下降。结果表明，老年DS患者的认知能力下降，但除了预期的随着年龄增长而出现的脑萎缩外，没有其他脑萎缩。
Quantitative CT demonstrated that healthy adults with Down's syndrome (DS) have smaller brains and smaller intracranial volumes than controls. Normalized volumes of CSF, ventricles, and brain parenchyma did not differ in patients and controls. Both DS subjects and controls showed similar significant age-related increments in volumes of CSF and ventricles. Of seven older DS subjects, one was demented, whereas the group as a whole showed reductions in cognitive test scores as compared with younger DS subjects. The results demonstrate cognitive decline in older DS subjects, but no brain atrophy other than that expected with aging.
阿尔茨海默病中的乳头体。
影响因子：
3.5
作者：
Grossi,D;Lopez,OL;Martinez,AJ
通讯作者：
Martinez,AJ
唐氏综合症中与年龄相关的神经心理缺陷。
影响因子：
10.6
作者：
Thase,ME;Tigner,R;Smeltzer,DJ;Liss,L
通讯作者：
Liss,L