Associations between polymorphisms in five inflammation-related genes and cognitive ability in older persons
Associations between polymorphisms in five inflammation-related genes and cognitive ability in older persons
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DOI：
10.1111/j.1601-183x.2010.00565.x
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Price, J. F.
中科院分区：
文献类型：
--
作者：
Marioni, R. E.;Deary, I. J.;Price, J. F.
一些研究发现炎症生物标志物水平与认知能力之间存在关联。这项研究测试了与生物标志物相关或编码生物标志物的基因多态性与认知能力和估计的终身认知变化之间的关系。数据来自阿司匹林治疗无症状动脉粥样硬化试验（n = 2091，平均年龄= 67.2岁）。从5个基因（IL-1 α、IL-1 β、IL-6、HNF-1A和F13 A1）中对12个单核苷酸多态性（SNP）进行基因分型。认知能力通过五项心理测量测试进行评估，这些测试用于得出一般智力因素g。还进行了基于词汇的认知测试，并在分析中进行了调整，以估计终身认知变化。年龄和性别调整分析得出IL-1 α rs 2856838 SNP与心理灵活性/处理速度测量之间存在一个弱显著相关性（P = 0.044）。对基于词汇的评分进行调整，结果显示IL-1 alpha rs3783546 SNP与处理速度测量之间存在单一的显著关联（P = 0.048）。几乎没有证据表明炎症相关基因IL-1 α、IL-1 β、IL-6、TCF-1和F13 A1中的SNP与居住在社区的苏格兰老年人的认知能力之间存在关联。
Several studies have found associations between inflammatory biomarker levels and cognitive ability. This study tested the relationship between polymorphisms in genes that are associated with or encode the biomarkers and cognitive ability and estimated lifetime cognitive change. Data came from the aspirin for asymptomatic atherosclerosis trial (n = 2091, mean age = 67.2 years ). Twelve single nucleotide polymorphisms (SNPs) were genotyped from five genes (IL-1 alpha, IL-1 beta, IL-6, HNF-1A and F13A1). Cognition was assessed via administration of a five-test battery of psychometric tests, which were used to derive a general intelligence factor, g. A vocabulary-based cognitive test was also administered and adjusted for in the analysis to enable an estimation of lifetime cognitive change. Age- and sex-adjusted analyses yielded one weakly significant association between the IL-1 alpha rs2856838 SNP and a measure of mental flexibility/processing speed (P = 0.044). Adjustment for the vocabulary-based scores resulted in a single, significant association between the IL-1 alpha rs3783546 SNP and a measure of processing speed (P = 0.048). There is little evidence to suggest an association between SNPs in the inflammation-related genes IL-1 alpha, IL-1 beta, IL-6, TCF-1 and F13A1 and cognition in an elderly population of community-dwelling Scottish citizens.