Versatile photosensitizers for photodynamic therapy at infrared excitation
Versatile photosensitizers for photodynamic therapy at infrared excitation
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DOI：
10.1021/ja0700707
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发表时间：
2007-04-18
影响因子：
15
通讯作者：
Scholfield, Matthew
中科院分区：
文献类型：
--
作者：
Zhang, Peng;Steelant, Wim;Scholfield, Matthew
报道了一种基于光子上转换纳米粒子的新型光动力学治疗光敏剂。这些光敏剂可被红外线照射激发，并且具有比目前可用的光敏剂大几倍的组织穿透深度。它们通过抗原-抗体相互作用接近靶癌细胞，具有良好的特异性和通用性。该设计也是灵活的，因为各种光敏分子可以潜在地被采用到设计中。体外实验结果表明，它们有望成为下一代光动力治疗药物。
A new type of photosensitizers used in photodynamic therapy, which is based on photon upconverting nanoparticles, is reported. These photosensitizers are excitable with infrared irradiation and have several times larger tissue penetration depth than the currently available ones. They are brought close to the target cancer cells through antigen-antibody interaction with good specificity and versatility. The design is also flexible in that various photosensitive molecules can be potentially adopted into the design. Results from in vitro experiments demonstrate their promise of becoming the next generation photodynamic therapy drugs.