Genetics and biology of pancreatic cancer and its precursor lesions: lessons learned from human pathology and mouse models
Genetics and biology of pancreatic cancer and its precursor lesions: lessons learned from human pathology and mouse models
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DOI：
10.21037/apc.2019.07.02
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发表时间：
2019-08
期刊：
影响因子：
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通讯作者：
Motoyuki Tsuda;A. Fukuda;K. Takaori;H. Seno
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文献类型：
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作者：
Motoyuki Tsuda;A. Fukuda;K. Takaori;H. Seno
胰腺导管腺癌（PDA）是最致命的恶性肿瘤之一；由于诊断较晚且对常规治疗的反应有限，其预后极差。为了改善 PDA 预后，迫切需要新的诊断和治疗策略。最近的基因组测序分析揭示了 PDA 中的几个突变的核心信号通路和转录组亚型。基于这些遗传见解更好地了解 PDA 生物学将促进新型诊断方法和治疗的未来发展。在这篇综述中，我们主要通过小鼠模型研究的见解总结了目前对 PDA 遗传学和生物学的理解。
Pancreatic ductal adenocarcinoma (PDA) is one of the most fatal malignancies; it has an extremely poor prognosis due to its late diagnosis and limited response to conventional treatments. To improve PDA prognosis, new diagnostic and treatment strategies are urgently required. Recent genomic sequencing analyses revealed several mutated core signaling pathways and transcriptomic subtypes in PDA. A better understanding of PDA biology based on these genetic insights would promote the future development of novel diagnostic methods and treatments. In this review, we summarize our current understanding of PDA genetics and biology, predominantly via insights from mouse model studies.