Universality and flexibility in gene expression from bacteria to human
Universality and flexibility in gene expression from bacteria to human
复制标题
DOI：
10.1073/pnas.0306244101
复制
发表时间：
2004-03-16
影响因子：
11.1
通讯作者：
Iino, M
中科院分区：
文献类型：
--
作者：
Ueda, HR;Hayashi, S;Iino, M
高度并行的生物学实验不仅为更轻松地完成工作提供了机会，也为探索潜在的指导原则提供了机会。最近对基因表达大规模组织的分析揭示了其复杂和动态的本质。然而，人们对产生复杂基因表达和细胞组织的基本动态还不了解。为了全面、定量地阐明这些潜在的基因表达动态，我们分析了大肠杆菌、酿酒酵母、拟南芥、黑腹果蝇、麝和智人在多种实验条件下的全基因组基因表达。在这里，我们证明了从大肠杆菌到人类，基因表达动态都遵循相同的、令人惊讶的简单原理，即基因表达变化与其表达水平成正比，并证明了这种 "成正比 "动态或 "富游更多 "机制可以再生出所观察到的转录组的复杂动态组织。这些发现提供了基因表达调控的普遍原则，展示了复杂的动态组织是如何从简单的基本动态中产生的，并证明了转录在各种表达水平上的灵活性。
Highly parallel experimental biology is offering opportunities to not just accomplish work more easily, but to explore for underlying governing principles. Recent analysis of the large-scale organization of gene expression has revealed its complex and dynamic nature. However, the underlying dynamics that generate complex gene expression and cellular organization are not yet understood. To comprehensively and quantitatively elucidate these underlying gene expression dynamics, we have analyzed genome-wide gene expression in many experimental conditions in Escherichia coli, Saccharomyces cerevisiae, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus, and Homo sapiens. Here we demonstrate that the gene expression dynamics follows the same and surprisingly simple principle from E. coli to human, where gene expression changes are proportional to their expression levels, and show that this "proportional" dynamics or "rich-travel-more" mechanism can regenerate the observed complex and dynamic organization of the transcriptome. These findings provide a universal principle in the regulation of gene expression, show how complex and dynamic organization can emerge from simple underlying dynamics, and demonstrate the flexibility of transcription across a wide range of expression levels.