Discordance in early breast cancer for tumour grade, Estrogen Receptor, Progesteron Receptors and Human Epidermal Receptor-2 status between core needle biopsy and surgical excisional primary tumour
Discordance in early breast cancer for tumour grade, Estrogen Receptor, Progesteron Receptors and Human Epidermal Receptor-2 status between core needle biopsy and surgical excisional primary tumour
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DOI：
10.1016/j.breast.2010.12.007
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发表时间：
2011-06-01
期刊：
影响因子：
3.9
通讯作者：
Pivot, Xavier
中科院分区：
文献类型：
--
作者：
Lorgis, Veronique;Algros, Marie Paule;Pivot, Xavier
本研究的目的是比较核心针吸活检(CNB)和切除原发肿瘤(EPT)中肿瘤分级、雌激素受体(ER)、孕激素受体(PGR)和人表皮受体-2(HER-2)的状态。纳入2005年1月1日至2006年12月31日在我校医院中心诊断为早期乳腺癌的所有患者，但排除大肿瘤需要新辅助化疗的患者和具有一个以上肿瘤(多中心/多病灶肿瘤)的患者。按Nottingham分级系统(SBRm)进行组织学分级，对CNB和EPT的ER、PGR和HER-2肿瘤状态进行两次评估，共175例患者进行评估。CNB与EPT的分级、ER、PgR、HER2状态的符合率分别为75.4%(p>；0.00001)、84%(p>；0.00002)、78.3%(p=0.002)和98.3%(p=0.486)。对于等级，由于CNB的结果有很大不一致，应谨慎使用PGR和ER。(C)2011爱思唯尔有限公司。保留所有权利。
The aim of the present study was to compare the tumour grade, Estrogen Receptor (ER), Progesteron Receptor (PgR) and Human Epidermal Receptor-2 (HER-2) status in the core needle biopsy (CNB) with those observed in the subsequent excisional primary tumour (EPT).All patients diagnosed with an early breast cancer in our University Hospital Center between January 1, 2005 and December 31, 2006 were included but exclusion criteria of patients with large tumour requiring neoadjuvant chemotherapy and cases with more than one tumour (multicentricity/multifocality tumours). Histological tumour grade assessed according to Nottingham Grading System (SBRm), ER, Pgr and HER-2 tumoural status were assessed twice in CNB and in EPT.A total of 175 patients were assessed. The concordance between CNB and EPT for Grade, ER, PgR and HER2 status were 75.4% (p > 0.00001), 84% (p > 0.00002), 78.3% (p = 0.002) and 98.3% (p = 0.486) respectively.In conclusion CNB can be used with confidence for HER2 determination. For grade, PgR and ER due to substantial discordance results from CNB should be used with caution. (C) 2011 Elsevier Ltd. All rights reserved.