Effect of norepinephrine on plasma vasopressin concentration and renal water metabolism.
Effect of norepinephrine on plasma vasopressin concentration and renal water metabolism.
复制标题
去甲肾上腺素对血浆加压素浓度和肾水代谢的影响。
DOI：
10.1159/000123088
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发表时间：
1980
影响因子：
4.1
通讯作者：
Share,L
中科院分区：
文献类型：
--
作者：
Kimura,T;Wang,BC;Crofton,JT;Share,L
在麻醉的、正常水分充足的狗中，i。 v.输注去甲肾上腺素（NE；0.5 µg/kg/min）导致血压升高，血浆加压素（ADH）浓度显着降低（2.6 ± 0.2 至 1.1 ± 0.2 µU/ml）。尿流量和渗透压清除率增加，尿渗透压下降。然而，尽管血浆 ADH 水平降低，但负游离水清除率 (TCH2O) 仍增加。因此，NE 诱导的利尿似乎主要是由于溶质排泄增加，但血浆 ADH 水平的降低也可能是一个因素。这些数据表明，当肾血流动力学和溶质排泄发生急剧变化时，自由水清除率的变化并不是血浆ADH浓度变化的令人满意的指标。去甲肾上腺素引起的 ADH 分泌减少似乎主要是由于动脉压力感受器活性增加，但不能排除中枢作用。
In the anesthetized, normally hydrated dog, the i. v. infusion of norepinephrine (NE; 0.5 µg/kg/min) resulted in an increased blood pressure and a marked reduction in the plasma vasopressin (ADH) concentration (2.6 ± 0.2 to 1.1 ± 0.2 µU/ml). Urine flow and osmolar clearance increased, and urine osmolality fell. However, the negative free water clearance (TCH2O) increased, despite the reduction in plasma ADH levels. Thus, the NE-induced diuresis appeared to be due largely to the increased solute excretion, but the reduction in plasma ADH levels may also have been a factor. These data show that change in free water clearance is not a satisfactory index of change in the plasma ADH concentration when there are acute changes in renal hemodynamics and solute excretion. The norepinephrine-induced reduction in ADH secretion appeared to be due largely to increased activity of the arterial baroreceptors, but a central action cannot be ruled out.