Induction of prolonged, continuous slow-wave sleep by blocking cerebral H1 histamine receptors in rats
Induction of prolonged, continuous slow-wave sleep by blocking cerebral H1 histamine receptors in rats
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DOI：
10.1111/j.1476-5381.2011.01547.x
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发表时间：
2012-01-01
影响因子：
7.3
通讯作者：
Ikeda, Masayuki
中科院分区：
文献类型：
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作者：
Ikeda-Sagara, Masami;Ozaki, Tomoya;Ikeda, Masayuki
背景和目的经典的H1组胺受体（H1R）拮抗剂对H1R是非选择性的，并且已知产生嗜睡。现代抗组胺药对H1R更具选择性，并且不嗜睡，可能是由于通过血脑屏障的渗透性降低。为了表征组胺能睡眠调节和抗组胺药的中枢作用，在本研究中，我们使用连续i.c.v.输注分析了经典和现代抗组胺药对大鼠睡眠的影响。
BACKGROUND AND PURPOSE Classic H1 histamine receptor (H1R) antagonists are non-selective for H1R and known to produce drowsiness. Modern antihistamines are more selective for H1R, and are non-drowsy presumably due to reduced permeability through the blood-brain barrier. To characterize both histaminergic sleep regulation and the central actions of antihistamines, in the present study we analysed the effect of classic and modern antihistamines on rats' sleep using continuous i.c.v. infusions.